van Weel C
Fam Pract. 1985 Sep;2(3):147-50. doi: 10.1093/fampra/2.3.147.
This study looked at the possible harmful effects of detection and treatment for hypertension. Patients with borderline blood pressure (diastolic 96-109 mmHg) were randomized into two groups: an intervention group receiving treatment for hypertension and a control group not told about any problem and left untreated. The morbidity in these two groups were studied for differences. During the period studied, the patients in the investigation group saw the doctor more frequently and had a larger number of diseases classified than the control group. When consultations involving hypertension and its follow up were excluded, however, no differences were demonstrable between the groups. Problem behaviour, psychosomatic and functional affections and symptom diagnoses were evenly distributed over the two groups. The difference in blood pressure between the two groups after completion of the study was not marked: the decrease in diastolic blood pressure averaged 7.6 mmHg in the control group versus 9.1 mmHg in the intervention group. In cases where the initial blood pressure values are only slightly raised, careful monitoring of blood pressure over a long period seems to be as effective as treatment for hypertension. The general practitioner should focus especially on anticipation in this sense.
本研究探讨了高血压检测与治疗可能产生的有害影响。血压临界(舒张压96 - 109 mmHg)的患者被随机分为两组:一组为接受高血压治疗的干预组,另一组为未被告知任何问题且未接受治疗的对照组。研究这两组的发病率差异。在研究期间,与对照组相比,调查组的患者看医生更频繁,被分类的疾病数量更多。然而,排除涉及高血压及其随访的会诊后,两组之间没有明显差异。问题行为、身心和功能性疾病以及症状诊断在两组中分布均匀。研究结束后,两组之间的血压差异并不显著:对照组舒张压平均下降7.6 mmHg,干预组为9.1 mmHg。在初始血压值仅略有升高的情况下,长期仔细监测血压似乎与高血压治疗同样有效。从这个意义上说,全科医生应特别注重预防。