血管内大B细胞淋巴瘤患者未满足的需求：三例病例报告及文献综述
Unmet needs of patients with intravascular large B-cell lymphoma: three case reports and a literature review.
作者信息
Li Xian, Luo Ru, Xu Jiaming, Jin Xueli, Wang Weiqin, Xiao Xibin, Qian Wenbin
机构信息
Department of Hematology, The Second Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou 310009, China.
Department of Pathology, The Second Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou 310009, China.
出版信息
J Zhejiang Univ Sci B. 2025 May 28;26(5):493-502. doi: 10.1631/jzus.B2300941.
Intravascular large B-cell lymphoma (IVLBCL), a rare subtype of non-Hodgkin lymphoma, is classified as an independent subtype of extranodal diffuse large B-cell lymphoma (DLBCL) in the 2008 World Health Organization (WHO) Classification (Turner et al., 2010). The 5th edition of the World Health Organization (WHO 2022) classification of hematolymphoid tumors retains this subtype (Alaggio et al., 2022). IVLBCL, which is characterized by neoplastic lymphocyte proliferation within the lumen of small blood vessels, tends to invade organs, such as the nervous system, skin, bone marrow (BM), and lung (D'Angelo et al., 2019; Satoh et al., 2019; Vásquez et al., 2019; Fukami et al., 2020).
血管内大B细胞淋巴瘤（IVLBCL）是一种罕见的非霍奇金淋巴瘤亚型，在2008年世界卫生组织（WHO）分类中被归类为结外弥漫性大B细胞淋巴瘤（DLBCL）的独立亚型（特纳等人，2010年）。世界卫生组织（WHO 2022）血液淋巴肿瘤分类第5版保留了该亚型（阿拉吉奥等人，2022年）。IVLBCL的特征是小血管腔内肿瘤性淋巴细胞增殖，倾向于侵犯神经系统、皮肤、骨髓（BM）和肺等器官（达安杰洛等人，2019年；佐藤等人，2019年；巴斯克斯等人，2019年；深见等人，2020年）。
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