Doskocil M
Gegenbaurs Morphol Jahrb. 1985;131(3):357-65.
The development of the human clavicle was studied in 50 to 60 d old human embryos. Our findings are summarized as follows: The whole clavicle develops from a cartilaginous anlage. In the middle part of the clavicle, an osseus cuff develops very early by the ossification in the perichondrium. In the lumen of this cuff, a cartilaginous cork persists which is resorbed and replaced by bone and marrow later than in other bones. It is possible that cartilaginous nests may persist in the middle part of the clavicle. In both extremities of the clavicle, the normal enchondral ossification exists as it is described in other anlages. It is difficult to explicate the syndrome of the cleido-facial and cleido-cranial dysostoses only as disturbances of the endesmal ossification.
在50至60日龄的人类胚胎中研究了人类锁骨的发育。我们的研究结果总结如下：整个锁骨由软骨原基发育而来。在锁骨中部，骨膜内的骨化很早就形成了一个骨袖。在这个骨袖的腔内，一块软骨栓持续存在，其被骨和骨髓吸收并替代的时间比其他骨骼要晚。锁骨中部可能会有软骨巢持续存在。在锁骨的两端，正常的软骨内成骨如在其他原基中所描述的那样存在。仅将锁骨面发育不全和锁骨颅骨发育不全综合征解释为膜内成骨的紊乱是难以说明的。
