Ogata S, Uhthoff H K
Department of Orthopedics, Chiba University, Japan.
Acta Orthop Scand. 1990 Aug;61(4):330-4. doi: 10.3109/17453679008993529.
Morphologic studies of the early development of the clavicle were carried out in 46 human embryos and fetuses ranging in age from 6 to 12 weeks. We confirmed that the clavicle is formed by two membranous primary ossification centers appearing by 6 weeks and fusing approximately 1 week later. Cartilage at both ends of the clavicle then develops. In time, the medial cartilaginous mass contributes more to the growth in length of the clavicle than the lateral cartilaginous mass. The spatial orientation of both ossification centers and the development of enchondral bone formation at the ends of the clavicle lead to its characteristic shape. Interestingly, the primary ossification centers contribute little to the growth in length. The junction of the two centers of ossification is situated between the lateral and middle third of the clavicle and, consequently, does not correspond to the site of congenital pseudarthrosis, which is located in the middle part of the clavicle.
对46例年龄在6至12周的人类胚胎和胎儿的锁骨早期发育进行了形态学研究。我们证实，锁骨由两个膜性初级骨化中心形成，这些中心在6周时出现，并在大约1周后融合。然后锁骨两端的软骨开始发育。随着时间的推移，内侧软骨块对锁骨长度增长的贡献比外侧软骨块更大。两个骨化中心的空间取向以及锁骨两端软骨内成骨的发育导致了其特有的形状。有趣的是，初级骨化中心对长度增长的贡献很小。两个骨化中心的交界处位于锁骨外侧和中三分之一之间，因此，并不对应于先天性假关节的部位，先天性假关节位于锁骨中部。
