总状轮环藤（防己科）提取物的胃肠道效应

Gastrointestinal effects of the extracts of Rhigiocarya racemifera (Menispermaceae).

作者信息

Aguwa C N

出版信息

Gen Pharmacol. 1985;16(4):387-90. doi: 10.1016/0306-3623(85)90201-0.

Abstract

The gastrointestinal effects of the aqueous extract of Rhigiocarya racemifera was studied in rats and was compared with that of cimetidine. Ulcers were induced in rats by means of drugs: indomethacin, reserpine and serotonin and by shay rats. The extract was found to have significant (P less than 0.05) antiulcer activity against all the models studied. The LD50 was found to be 141.25 mg/kg body weight and ED50 16.5 mg/kg. Phytochemical studies revealed the presence of glycosides, saponins, and tanins. The extract does not show antimicrobial effects.

摘要

研究了总状毛麝香（Rhigiocarya racemifera）水提取物对大鼠的胃肠道作用，并与西咪替丁进行了比较。通过药物（吲哚美辛、利血平和血清素）以及通过幽门结扎法在大鼠中诱导溃疡形成。结果发现，该提取物对所有研究模型均具有显著（P<0.05）的抗溃疡活性。其半数致死量（LD50）为141.25毫克/千克体重，半数有效量（ED50）为16.5毫克/千克。植物化学研究表明存在糖苷、皂苷和单宁。该提取物未显示出抗菌作用。