使用大鼠实验性胃溃疡的各种模型研究刺核藤（茶茱萸科）叶水提取物的抗溃疡活性。

Study of antiulcer activity of aqueous extract of leaves of Pyrenacantha staudtii (family Icacinaceae) using various models of experimental gastric ulcer in rats.

作者信息

Aguwa C N, Mittal G C

出版信息

Eur J Pharmacol. 1981 Sep 11;74(2-3):215-9. doi: 10.1016/0014-2999(81)90533-1.

Abstract

The antiulcer activity of an aqueous extract of Pyrenacantha staudtii was studied in rats and was compared with that of cimetidine. Ulcers were induced in rats by means of various experimental models: aspirin, indomethacin, serotonin and reserpine. The extract was found to have significant antiulcer activity against all the models studied. Cimetidine was found to be ineffective against serotonin- and reserpine-induced ulcers.

摘要

对刺核藤水提取物的抗溃疡活性进行了大鼠实验研究，并与西咪替丁进行了比较。通过多种实验模型在大鼠中诱导溃疡：阿司匹林、消炎痛、血清素和利血平。结果发现该提取物对所有研究模型均具有显著的抗溃疡活性。发现西咪替丁对血清素和利血平诱导的溃疡无效。