Wang Ziqing, Wallace Danielle A, Spitzer Brian W, Huang Tianyi, Taylor Kent D, Rotter Jerome I, Rich Stephen S, Liu Peter Y, Daviglus Martha L, Hou Lifang, Ramos Alberto R, Kaur Sonya, Durda J Peter, González Hector M, Fornage Myriam, Redline Susan, Isasi Carmen R, Sofer Tamar
Cardiovascular Institute, Beth Israel Deaconess Medical Center, Boston, MA, USA.
Department of Medicine, Harvard Medical School, Boston, MA, USA.
Commun Biol. 2025 May 28;8(1):821. doi: 10.1038/s42003-025-08226-1.
C-reactive protein (CRP) reflects inflammation status and is linked to poor sleep, metabolic and cardiovascular health. Methylation (MRS) and polygenic risk scores (PRS) reflect long-term systemic inflammation, and genetically-determined CRP, respectively. To refine understanding of inflammation-linked sleep and health outcomes, we construct PRS-CRPs using GWAS summary statistics and a previously-developed MRS-CRP in the Hispanic Community Health Study/Study of Latinos. Via survey-weighted linear regression, we estimate associations between blood-, PRS-, and MRS-CRP, with multiple sleep and health outcomes (n = 2217). MRS-CRP and PRS-CRPs are associated with increasing blood-CRP level by 43% and 23% per standard deviation. MRS-CRP is associated with obstructive sleep apnea (OSA) traits, long sleep duration, diabetes and hypertension, while PRS-CRPs were not. Blood-CRP level is associated with sleep duration and diabetes. Adjusting for MRS-CRP weakens OSA-diabetes/hypertension associations. Consequently, MRS-CRP is a stronger marker than blood-CRP and PRS-CRP to systemic inflammation associated with poor sleep and related comorbidities.
C反应蛋白（CRP）反映炎症状态，且与睡眠不佳、代谢和心血管健康相关。甲基化评分（MRS）和多基因风险评分（PRS）分别反映长期全身性炎症和基因决定的CRP。为了更深入地理解与炎症相关的睡眠和健康结果，我们在西班牙裔社区健康研究/拉丁裔研究中，利用全基因组关联研究（GWAS）汇总统计数据和先前开发的MRS-CRP构建了PRS-CRP。通过调查加权线性回归，我们估计血液CRP、PRS-CRP和MRS-CRP与多种睡眠和健康结果（n = 2217）之间的关联。MRS-CRP和PRS-CRP每增加一个标准差，血液CRP水平分别升高43%和23%。MRS-CRP与阻塞性睡眠呼吸暂停（OSA）特征、长睡眠时间、糖尿病和高血压相关，而PRS-CRP则不然。血液CRP水平与睡眠时间和糖尿病相关。校正MRS-CRP后，OSA与糖尿病/高血压之间的关联减弱。因此，对于与睡眠不佳及相关合并症相关的全身性炎症，MRS-CRP是比血液CRP和PRS-CRP更强的标志物。
