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视网膜退行性疾病基因治疗的临床试验概况:基于Trialtrove数据库的分析

Clinical trial landscape of gene therapy for retinal degenerative diseases: an analysis based on the Trialtrove database.

作者信息

Cheng Shizhou, Xing Chuyun, Chen Zijian, Zhang Shu, Chen Wanghao

机构信息

Department of Ophthalmology, The First Affiliated Hospital of Yangtze University, Jingzhou, 434000, Hubei Province, China.

Department of Pain Management, The First Affiliated Hospital of Yangtze University, Jingzhou, 434000, Hubei Province, China.

出版信息

Stem Cell Res Ther. 2025 May 28;16(1):257. doi: 10.1186/s13287-025-04387-2.

Abstract

Gene therapy has changed the way retinal degenerative diseases are explored and treated. Analyzing past and ongoing clinical trials using gene therapy for retinal degenerative diseases will provide important insight into academic, medical, and other communities. This study retrospectively analyzed 209 clinical trials in the Trialtrove database initiated before 2025.

摘要

基因治疗改变了视网膜退行性疾病的研究和治疗方式。分析过去和正在进行的使用基因治疗视网膜退行性疾病的临床试验,将为学术界、医学界和其他团体提供重要的见解。本研究回顾性分析了Trialtrove数据库中在2025年前启动的209项临床试验。

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