上颌骨纤维肉瘤伴上颌窦侵犯：一例报告并文献复习
Fibrosarcoma of the maxilla with maxillary sinus invasion: a case report and review of the literature.
作者信息
Mahdavi Nazanin, Derakhshan Samira, Etemadi Mahsa
机构信息
Department of Oral and Maxillofacial Pathology, School of Dentistry, Tehran University of Medical Sciences, Tehran, Iran.
Department of Periodontics, School of Dentistry, Mashhad University of Medical Sciences, Mashhad, Iran.
出版信息
J Med Case Rep. 2025 May 28;19(1):254. doi: 10.1186/s13256-025-05279-y.
BACKGROUND
Fibrosarcoma is a rare, invasive soft tissue sarcoma that is more common in males aged 30-60 years. It accounts for 1% of all malignancies in the human body. Treatment is radical surgical removal, radiotherapy, and chemotherapy.
CASE PRESENTATION
A 58-year-old Khorasani Persian male patient with a complaint of expansion, pain, and paresthesia in the left maxillary quadrant was diagnosed with infiltrative high-grade sarcoma. Tumoral cells were strongly diffuse positive for vimentin and negative for S100 and desmin, indicating high-grade adult fibrosarcoma.
CONCLUSION
This report presents a rare case of a fibrosarcoma causing paresthesia, pain, and expansion in the maxilla with maxillary sinus invasion, which requires early diagnosis and immediate referral.
背景
纤维肉瘤是一种罕见的侵袭性软组织肉瘤，在30至60岁男性中更为常见。它占人体所有恶性肿瘤的1%。治疗方法为根治性手术切除、放疗和化疗。
病例介绍
一名58岁的霍拉桑波斯男性患者，主诉左上颌象限肿胀、疼痛和感觉异常，被诊断为浸润性高级别肉瘤。肿瘤细胞波形蛋白呈强弥漫性阳性，S100和结蛋白呈阴性，提示为高级别成人纤维肉瘤。
结论
本报告展示了一例罕见的纤维肉瘤病例，该肿瘤导致上颌感觉异常、疼痛和肿胀，并侵犯上颌窦，需要早期诊断并立即转诊。
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