Huang Yuxing, Huang Yi, Gao Jian
Department of Obstetrics and Gynecology, Peking University First hospital, Beijing, China.
Department of Respiratory Medicine, Nankang Hospital of Traditional Chinese Medicine, Ganzhou, Jiangxi, China.
Cell Biosci. 2025 May 28;15(1):70. doi: 10.1186/s13578-025-01417-7.
The migrasome, an organelle that forms behind migrating cells, is connected to the cell body by a retraction fiber. Once released from the retraction fiber, the migrasome transforms into an extracellular vesicle and plays important roles in cell communication, development, angiogenesis, and disease. To date, the biogenesis, regulation of formation, cargo transportation, and physiological functions of migrasomes remain largely unknown. In this review, we summarize the current understanding of the mechanisms underlying migrasome formation and regulation, describe the evidence suggesting that migrasomes serve various physiological functions, compare the differences between migrasomes and other extracellular vesicles, emphasize the limitations in studying migrasomes, and discuss the potential of migrasomes in disease diagnosis and treatment.
迁移小体是一种在迁移细胞后方形成的细胞器，通过收缩纤维与细胞体相连。一旦从收缩纤维上释放，迁移小体就会转变为细胞外囊泡，并在细胞通讯、发育、血管生成和疾病中发挥重要作用。迄今为止，迁移小体的生物发生、形成调控、货物运输和生理功能在很大程度上仍不清楚。在这篇综述中，我们总结了目前对迁移小体形成和调控机制的理解，描述了表明迁移小体具有多种生理功能的证据，比较了迁移小体与其他细胞外囊泡的差异，强调了研究迁移小体的局限性，并讨论了迁移小体在疾病诊断和治疗中的潜力。
