Department of Biology, University of Rome "Tor Vergata", Rome, Italy.
Biol Direct. 2022 Apr 28;17(1):8. doi: 10.1186/s13062-022-00321-1.
Migrasomes, released by migrating cells, belong to the heterogeneous world of extracellular vesicles (EVs). However, they can be distinguished from all other members of EVs by their size, biorigin and protein cargo. As far as we know, they can play important roles in various communication processes, by mediating the release of signals, such as mRNAs, proteins or damaged mitochondria. To extend and better understand the functional roles and importance of migrasomes, it is first essential to well understand the basic molecular mechanisms behind their formation and function. Herein, we endeavor to provide a brief and up-to-date description of migrasome biogenesis, release, characterization, biological properties and functional activities in cell-to-cell communication, and we will discuss and propose putative new functions for these vesicles.
迁移小体由迁移细胞释放，属于细胞外囊泡 (EVs) 的异质世界。然而，它们可以通过其大小、生物起源和蛋白 cargo 与所有其他 EV 成员区分开来。据我们所知，它们可以通过介导信号（如 mRNAs、蛋白质或受损的线粒体）的释放，在各种通信过程中发挥重要作用。为了扩展和更好地理解迁移小体的功能作用和重要性，首先必须很好地理解它们形成和功能的基本分子机制。在此，我们努力简要而最新地描述迁移小体的生物发生、释放、特征、细胞间通讯中的生物学特性和功能活性，并将讨论和提出这些囊泡的新功能。
