Qian Qiuxia, Zhao Yuting, Fan Xin, Li Jialu, Cao Jianxun, Yang Mengyu, Hua Longchun, Zhang Xingxia, Yang Ailing, Zhang Fengwa, Ma Yuxia
Evidence-Based Nursing Center, School of Nursing, Lanzhou University, Lanzhou, China.
The First Hospital, Lanzhou University, Lanzhou, Gansu, China.
Brain Behav. 2025 Jun;15(6):e70550. doi: 10.1002/brb3.70550.
To explore the relationship between body mass index (BMI) and the recurrence risk of stroke.
We searched databases, including the Web of Science, Cochrane Library, Embase, PubMed, Chinese Biomedical Literature (CBM), CQVIP, WanFang Database, and China National Knowledge Infrastructure (CNKI), from inception to February 2025, to collect literature on BMI and the recurrence risk of stroke. After two researchers independently screened the literature, extracted the literature data, and assessed the quality of the literature included in the study, a meta-analysis was conducted using Stata 16.0 software, and the dose-response relationship between BMI and the recurrence risk of stroke was analyzed using generalized least squares trend estimation method (GLST) and restricted cubic spline function.
A total of 18 studies were included, involving 165,366 patients. In terms of stroke recurrence risk, compared with normal-weight patients, underweight patients [relative risk (RR) = 1.59, 95% confidence interval (CI) 1.33-1.90, I = 0%, p = 0.444] had a higher recurrence risk of stroke, whereas overweight (RR = 0.91, 95% CI 0.86-0.96, I = 0%, p = 0.454) and obese patients (RR = 0.89, 95% CI 0.84-0.94, I = 13.1%, p = 0.330) had a lower recurrence risk of stroke. The results of the linear trend show that for every unit increase in BMI, the recurrence risk of stroke decreases by 2% (RR = 0.98, 95% CI 0.96-0.99, p < 0.001).
Increased BMI is associated with a decreased recurrence risk of stroke. Underweight is a risk factor for stroke recurrence, whereas overweight and obesity are protective factors for stroke recurrence. Overweight and obesity may be beneficial for secondary prevention in stroke patients.
Not applicable.
探讨体重指数（BMI）与中风复发风险之间的关系。
检索截至2025年2月的数据库，包括Web of Science、Cochrane图书馆、Embase、PubMed、中国生物医学文献数据库（CBM）、维普资讯、万方数据库和中国知网，以收集有关BMI与中风复发风险的文献。两名研究人员独立筛选文献、提取文献数据并评估纳入研究的文献质量后，使用Stata 16.0软件进行荟萃分析，并采用广义最小二乘趋势估计法（GLST）和受限立方样条函数分析BMI与中风复发风险之间的剂量反应关系。
共纳入18项研究，涉及165366例患者。在中风复发风险方面，与正常体重患者相比，体重过轻的患者[相对风险（RR）=1.59，95%置信区间（CI）1.33-1.90，I²=0%，p=0.444]中风复发风险更高，而超重（RR=0.91，95%CI 0.86-0.96，I²=0%，p=0.454）和肥胖患者（RR=0.89，95%CI 0.84-0.94，I²=13.1%，p=0.330）中风复发风险较低。线性趋势结果显示，BMI每增加一个单位，中风复发风险降低2%（RR=0.98，95%CI 0.96-0.99，p<0.001）。
BMI升高与中风复发风险降低相关。体重过轻是中风复发的危险因素，而超重和肥胖是中风复发的保护因素。超重和肥胖可能对中风患者的二级预防有益。
不适用。
