Evidence-Based Nursing Center, School of Nursing of Lanzhou University, Lanzhou, China.
School of Nursing, Lanzhou University, No.28, West Yan Road, Chengguan District, Lanzhou, Gansu Province, China.
J Neurol. 2022 Dec;269(12):6279-6289. doi: 10.1007/s00415-022-11318-1. Epub 2022 Aug 15.
Stroke is an acute cerebrovascular event closely related to brain tissue damage, and is one of the major causes of death and disability in worldwide. Various studies have reported the effects of body mass index (BMI) on the risk of stroke, but the results remain varied and these results have not been synthesized. Therefore, a meta-analysis was performed to evaluate the relationship between BMI and the risk of stroke.
This systematic review was conducted to explore the relationship between BMI and the risk of stroke.
PubMed, EMBASE, Web of Science and Cochrane Library, China Knowledge Resource Integrated Database (CNKI), WanFang Database, Chinese Biomedical Database (CBM), and CQVIP were comprehensively searched for studies exploring the relationship between BMI and stroke from inception to December 1, 2021.
This review included 24 studies involving 5,798,826 subjects. The results of meta-analysis showed that the pooled RR of stroke risk was 0.93 (95% confidence interval [CI] 0.82-1.06, I = 88.8%, P = 0.29) for the underweight group. Higher BMI (overweight or obese group) was associated with an increased overall risk of stroke, with pooled RR values of 1.25 (95% CI 1.16-1.34, I = 84.8%, P = 0.00) and 1.47 (95% CI: 1.02-2.11, I = 99.4%, P = 0.04).
The risk of stroke was positively correlated with BMI, and the association was stronger in male and ischemic stroke. Lowering BMI can be used as a way to prevent stroke, and for people who are overweight or obese, lowering body weight can reduce the risk of stroke.
中风是一种与脑组织损伤密切相关的急性脑血管事件，是全球范围内主要的死亡和残疾原因之一。多项研究报告了体重指数（BMI）对中风风险的影响，但结果仍存在差异，这些结果尚未得到综合。因此，进行了荟萃分析以评估 BMI 与中风风险之间的关系。
本系统评价旨在探讨 BMI 与中风风险之间的关系。
全面检索了 PubMed、EMBASE、Web of Science 和 Cochrane Library、中国知识资源总库（CNKI）、万方数据库、中国生物医学文献数据库（CBM）和维普数据库，以检索从成立到 2021 年 12 月 1 日探讨 BMI 与中风关系的研究。
本综述纳入了 24 项研究，共涉及 5798826 名受试者。荟萃分析结果显示，体重不足组中风风险的合并 RR 为 0.93（95%置信区间 [CI] 0.82-1.06，I = 88.8%，P = 0.29）。较高的 BMI（超重或肥胖组）与总体中风风险增加相关，合并 RR 值分别为 1.25（95%CI 1.16-1.34，I = 84.8%，P = 0.00）和 1.47（95%CI：1.02-2.11，I = 99.4%，P = 0.04）。
中风风险与 BMI 呈正相关，这种相关性在男性和缺血性中风中更强。降低 BMI 可以作为预防中风的一种方法，对于超重或肥胖的人来说，降低体重可以降低中风风险。
