Plyduang Thipapun, Maneewattanapinyo Pattwat, Monton Chaowalit, Pichayakorn Wiwat, Panrat Kamon, Suksaeree Jirapornchai
School of Pharmacy, Walailak University, Nakhon Si Thammarat 80160, Thailand.
Drug and Cosmetics Excellence Center Walailak University, Nakhon Si Thammarat 80160, Thailand.
Adv Pharmacol Pharm Sci. 2025 May 21;2025:1305224. doi: 10.1155/adpp/1305224. eCollection 2025.
The potential uses of extracting mucilage from plant sources have led to much research in this field. One possible source of mucilage for agri-food-pharma utilization is the fruits of the , date palm. For developing the plaster gel loaded with nicotine, we, therefore, applied the mucilage from date palm fruits as a gel-forming agent. Other components, however, might be added to increase its properties. Response surface methodology was used for quantifying the effects of a range of variables (date palm mucilage, PVA, and glycerin) on physicochemical parameters (pH value, viscosity, drying time, ultimate tensile strength, elongation at break, and drug content). The optimal formulation was 3.5%:1.8%:30% w/w. The resultants were 6.14 ± 0.05, 45.67 ± 1.75 cp, 14.77 ± 1.19 min, 26.83 ± 2.15 MPa, 38.20 ± 2.39%, and 9.51 ± 0.19 mg/g, respectively. The optimal formulation of nicotine-containing plaster gel had a semicrystalline structure as it was derived from plant mucilage. It was immediately obvious that the formulation might control the release of nicotine, indicating first-order kinetic release. The and values were 0.30 ± 0.01 mg/cm/h and 3.13 ± 0.11 × 10 cm/h, respectively, indicating a maximum nicotine permeation of 78.82 ± 13.57%. When stored in a refrigerator as compared to room temperature, the nicotine-loading plaster gel thus showed excellent physical stability.
从植物来源提取黏液的潜在用途引发了该领域的大量研究。枣椰树果实是农业食品制药领域黏液的一种可能来源。因此，为了开发负载尼古丁的膏药凝胶，我们将枣椰树果实黏液用作凝胶形成剂。然而，可能需要添加其他成分来改善其性能。采用响应面法来量化一系列变量（枣椰树黏液、聚乙烯醇和甘油）对理化参数（pH值、粘度、干燥时间、极限拉伸强度、断裂伸长率和药物含量）的影响。最佳配方为3.5%:1.8%:30% w/w。所得结果分别为6.14±0.05、45.67±1.75 cp、14.77±1.19分钟、26.83±2.15 MPa、38.20±2.39%和9.51±0.19 mg/g。含尼古丁膏药凝胶的最佳配方具有半结晶结构，因为它源自植物黏液。很明显，该配方可能控制尼古丁的释放，表明为一级动力学释放。其 和 值分别为0.30±0.01 mg/cm/h和3.13±0.11×10 cm/h，表明尼古丁的最大渗透率为78.82±13.57%。与室温相比，将含尼古丁的膏药凝胶储存在冰箱中时，其显示出优异的物理稳定性。
