van den Besselaar A M
Haemostasis. 1985;15(4):271-7. doi: 10.1159/000215159.
The establishment of International Reference Preparations for thromboplastin together with a recommended methodology for use has permitted the definition of a universal scale for intensity of oral anticoagulation. This scale is called International Normalized Ratio (INR). INRs can be calculated by using calibrated thromboplastin/instrument systems. A calibration model has been developed together with statistical methods to test this model. The imprecision of calculated INRs has been estimated using information from international collaborative studies and proficiency testing programs. Normalized prothrombin times obtained with calibrated thromboplastin/instrument systems have been shown to provide safe patient care in clinical practice. The development of control plasmas with assigned INR equivalents will complete the standardization system. The INR scale will facilitate the process of consensus-making with respect to optimal therapeutic ranges for anticoagulant intensity. Finally, it will improve the continuity of anticoagulant control of travelling patients.
凝血活酶国际参考制剂的建立以及推荐的使用方法，使得口服抗凝强度的通用标准得以确定。这个标准称为国际标准化比值（INR）。INR可通过使用校准的凝血活酶/仪器系统来计算。已经开发了一个校准模型以及用于测试该模型的统计方法。利用国际协作研究和能力验证计划的信息，对计算得到的INR的不精密度进行了估计。已证明使用校准的凝血活酶/仪器系统获得的标准化凝血酶原时间在临床实践中可为患者提供安全的护理。具有指定INR等效值的对照血浆的开发将完善标准化系统。INR标准将有助于就抗凝强度的最佳治疗范围达成共识。最后，它将改善旅行患者抗凝控制的连续性。
