Stuart Amanda L, Berk Michael, Pasco Julie A, Mohebbi Mohammadreza, Quirk Shae E, Williams Lana J
IMPACT- Institute for Mental and Physical Health and Clinical Translation, School of Medicine, Deakin University, Geelong, VIC, Australia.
Florey Institute for Neuroscience and Mental Health, University of Melbourne, Parkville, VIC, Australia.
Front Glob Womens Health. 2025 May 14;6:1501382. doi: 10.3389/fgwh.2025.1501382. eCollection 2025.
Bipolar disorder is associated with several physical conditions and possibly increased pain, although research outside hospital settings is limited. We compared perceived pain among population-based women with and without bipolar disorder.
This study examined 113 women with bipolar disorder (59 euthymic, 54 symptomatic in past month) and 316 age-matched women without bipolar disorder drawn from studies located in the same region of south-eastern Australia. Mental disorders were confirmed by clinical interview (SCID-I/NP). Pain during the past week was determined by numeric rating scale (0-10, 10 = pain as severe as I can imagine) and deemed present if ≥5. Demographic, lifestyle, and health information was obtained via questionnaire. Odds ratios (OR) with 95% confidence intervals for the likelihood of pain were estimated using marginal binary logistic regression models, adjusting for potential confounders.
Women with bipolar disorder who were euthymic at the appointment were at increased odds of headache [adjOR 3.4, 95% CI (1.4, 7.9)], back pain [2.6 (1.3, 5.4)], overall pain(s) [5.7 (2.9, 11.4)], pain at ≥3 sites [2.3 (1.0, 5.2)] and were in pain ≥50% time spent awake [2.3 (1.1, 5.1)] compared to women without bipolar disorder. The pattern of association was similar but stronger for women symptomatic in the past month; headache [6.0 (2.6, 13.9)], back pain [4.2 (2.0, 8.5)], overall pain(s) [7.2 (3.4, 15.4)], pain at ≥3 sites [5.1 (2.3, 11.1)] and ≥50% time in pain [4.5 (2.2, 9.3)]. Daily activity interference from pain did not differ between groups (all > 0.05).
Women with bipolar disorder are more likely to report pain regardless of phase. Assessment and management of pain is necessary to reduce associated burden.
双相情感障碍与多种身体状况相关，且可能会加剧疼痛，不过医院环境以外的相关研究有限。我们比较了患有和未患有双相情感障碍的成年女性群体中的疼痛感受。
本研究调查了113名患有双相情感障碍的女性（59名处于心境正常期，54名在过去一个月内有症状）以及316名年龄匹配的未患双相情感障碍的女性，这些女性来自澳大利亚东南部同一地区的研究。通过临床访谈（SCID-I/NP）确诊精神障碍。过去一周的疼痛情况通过数字评分量表确定（0至10分，10分表示我能想象到的最严重疼痛），若评分≥5分则判定为疼痛。通过问卷获取人口统计学、生活方式和健康信息。使用边际二元逻辑回归模型估计疼痛可能性的比值比（OR）及其95%置信区间，并对潜在混杂因素进行调整。
就诊时处于心境正常期的双相情感障碍女性出现头痛的几率增加[校正OR为3.4，95%置信区间（1.4，7.9）]，背痛[2.6（1.3，5.4）]，全身疼痛[5.7（2.9，11.4）]，在≥3个部位疼痛[2.3（1.0，5.2）]，以及在清醒时间里≥50%的时间处于疼痛状态[2.3（1.1，5.1）]，与未患双相情感障碍的女性相比。对于过去一个月内有症状的女性，关联模式相似但更强；头痛[6.0（2.6，13.9）]，背痛[4.2（2.0，8.5）]，全身疼痛[7.2（3.4，15.4）]，在≥3个部位疼痛[5.1（2.3，11.1）]，以及≥50%的时间处于疼痛状态[4.5（2.2，9.3）]。两组之间疼痛对日常活动的干扰没有差异（均>0.05）。
无论处于哪个阶段，双相情感障碍女性更有可能报告疼痛。有必要对疼痛进行评估和管理，以减轻相关负担。
