Yuan Shuai, Furniss Dominic, Larsson Susanna C, Leffler Daniel A, Ludvigsson Jonas F
Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden.
Nuffield Department of Orthopaedics, Rheumatology, and Musculoskeletal Sciences, University of Oxford, Oxford, UK.
Clin Epidemiol. 2025 May 24;17:481-484. doi: 10.2147/CLEP.S518939. eCollection 2025.
This study explored the association between celiac disease (CeD) and Dupuytren's contracture (DC) using data from the Swedish ESPRESSO cohort. We analyzed 49,699 CeD patients and 245,267 matched controls, identifying 1420 incident DC cases. CeD patients had a 1.21-fold increased risk of DC compared to controls, with a more pronounced risk in women and older individuals. Further research is needed to understand the underlying mechanisms of this relationship.
本研究利用瑞典ESPRESSO队列的数据，探讨了乳糜泻（CeD）与杜普伊特伦挛缩症（DC）之间的关联。我们分析了49699例CeD患者和245267例匹配的对照，确定了1420例新发DC病例。与对照组相比，CeD患者发生DC的风险增加了1.21倍，女性和老年人的风险更为明显。需要进一步研究以了解这种关系的潜在机制。
