Spitalny G L, North R J
J Exp Med. 1977 May 1;145(5):1264-77. doi: 10.1084/jem.145.5.1264.
Mice carrying any one of three murine tumors in their right hind foot pad were incapable of eliminating an inoculum of the bacterial parasite Listeria monocytogenes from the progressive tumor. In contrast, they were as capable as control mice in efficiently eliminating the organism from their contralateral tumor-free foot pad, and from their lymph nodes and livers. The results serve to show, therefore, that conditions within an established tumor are not only antagonistic to the expression of concomitant anti-tumor immunity, but that they are also antagonistic to the expression of T-cell-mediated anti-bacterial immunity. The possibility was discussed that the tumor contains factors that act pharmacologically to locally suppress the function of sensitized T cells and activated macrophages.
右后脚垫携带三种鼠类肿瘤之一的小鼠无法从进行性肿瘤中清除细菌寄生虫单核细胞增生李斯特菌的接种物。相比之下，它们在从对侧无肿瘤的脚垫、淋巴结和肝脏中有效清除该病原体方面与对照小鼠一样有能力。因此，结果表明，既定肿瘤内的条件不仅对抗伴随的抗肿瘤免疫的表达，而且也对抗T细胞介导的抗细菌免疫的表达。有人讨论了肿瘤中含有在药理上局部抑制致敏T细胞和活化巨噬细胞功能的因子的可能性。
