Fame Ryann M
Department of Neurosurgery, Stanford University, Stanford, CA USA.
NPJ Biol Timing Sleep. 2025;2(1):19. doi: 10.1038/s44323-025-00033-5. Epub 2025 May 26.
Cerebrospinal fluid (CSF) exchanges with the central nervous system's immediate environment and interfaces with systemic circulation at the blood-CSF barrier. CSF composition reflects brain states, contributes to brain health and disease, is modulated by circadian rhythms and behaviors, and turns over multiple times per day, enabling rapid signal relay. Mechanisms of how CSF elements change over circadian time and influence function can be harnessed for diagnostic biomarkers and therapeutic intervention.
脑脊液（CSF）与中枢神经系统的直接环境进行交换，并在血脑屏障处与体循环相互作用。脑脊液的成分反映脑状态，对脑健康和疾病有影响，受昼夜节律和行为调节，且每天周转多次，从而实现快速信号传递。脑脊液成分如何随昼夜时间变化以及如何影响功能的机制可用于诊断生物标志物和治疗干预。
