National Institute of Molecular Genetics and Biosciences Department, University of Milan, Milan, Italy.
Department of Cellular and Molecular Pharmacology, Department of Urology, Helen Diller Family Comprehensive Cancer Center, University of California, San Francisco, San Francisco, CA, USA.
Cell Metab. 2024 Sep 3;36(9):1945-1962. doi: 10.1016/j.cmet.2024.07.022.
Metabolism and mRNA translation represent critical steps involved in modulating gene expression and cellular physiology. Being the most energy-consuming process in the cell, mRNA translation is strictly linked to cellular metabolism and in synchrony with it. Indeed, several mRNAs for metabolic pathways are regulated at the translational level, resulting in translation being a coordinator of metabolism. On the other hand, there is a growing appreciation for how metabolism impacts several aspects of RNA biology. For example, metabolic pathways and metabolites directly control the selectivity and efficiency of the translational machinery, as well as post-transcriptional modifications of RNA to fine-tune protein synthesis. Consistently, alterations in the intricate interplay between translational control and cellular metabolism have emerged as a critical axis underlying human diseases. A better understanding of such events will foresee innovative therapeutic strategies in human disease states.
代谢和 mRNA 翻译代表了调节基因表达和细胞生理学的关键步骤。作为细胞中最耗能的过程，mRNA 翻译与细胞代谢严格相关，并与之同步。事实上，代谢途径的几个 mRNA 在翻译水平上受到调节，导致翻译成为代谢的协调者。另一方面，人们越来越认识到代谢如何影响 RNA 生物学的几个方面。例如，代谢途径和代谢物直接控制翻译机制的选择性和效率，以及 RNA 的转录后修饰，以微调蛋白质合成。一致地，翻译控制和细胞代谢之间复杂相互作用的改变已成为人类疾病的关键轴。更好地理解这些事件将为人类疾病状态下的创新治疗策略提供预见。
