Gaur Malvika, Sehgal Tushar, Bharti Ginni, Babu Hemapriya J, Xess Immaculata
Laboratory Medicine, All India Institute of Medical Sciences, New Delhi, New Delhi, IND.
Microbiology, All India Institute of Medical Sciences, New Delhi, New Delhi, IND.
Cureus. 2025 Apr 28;17(4):e83129. doi: 10.7759/cureus.83129. eCollection 2025 Apr.
Invasive fungal infections (IFIs) are a significant cause of morbidity and mortality in hospitalized patients, particularly among neonates and immunocompromised individuals. species are one of the most commonly associated pathogens associated with IFIs. We present a case series of four patients with IFIs. All cases underwent peripheral blood film (PBF) examination, blood culture, and serum galactomannan testing. Budding yeasts were found in the PBF of three out of four cases. The findings were confirmed by culture. While blood culture remains the gold standard for diagnosing IFIs, the PBF test demonstrated its value as a rapid and cost-effective initial screening tool, especially in resource-limited settings. PBF tests can offer valuable preliminary insights, facilitating further diagnostic evaluation and early initiation of antifungal therapy. These findings underscore the potential utility of PBF tests in the early detection and management of IFIs.
侵袭性真菌感染（IFI）是住院患者发病和死亡的重要原因，尤其是在新生儿和免疫功能低下者中。 属是与IFI最常相关的病原体之一。我们报告了一组4例IFI患者的病例系列。所有病例均接受了外周血涂片（PBF）检查、血培养和血清半乳甘露聚糖检测。4例中有3例在PBF中发现了芽生酵母。培养结果证实了这些发现。虽然血培养仍然是诊断IFI的金标准，但PBF检测显示出其作为一种快速且经济高效的初始筛查工具的价值，尤其是在资源有限的环境中。PBF检测可以提供有价值的初步见解，有助于进一步的诊断评估和早期启动抗真菌治疗。这些发现强调了PBF检测在IFI早期检测和管理中的潜在效用。
