Van Os Luc, Cassoux Nathalie, Cholidis Symira, Dureau Pascal, Farassat Navid, Fierz Fabienne Catherine, Ghyczy Ebba, Nitulescu Elena-Cristina, Stifter Eva, Tassignon Marie-José, Le Flèche-Matéos Anne, Lorenz Birgit
Emerg Infect Dis. 2025 Jun;31(6):1081-1089. doi: 10.3201/eid3106.240954.
Spiroplasma ixodetis has been reported to cause the rare combination of cataract and uveitis in infants. Through a retrospective analysis of available literature and additional unpublished cases, we identified 28 eyes from 18 infants from 8 countries in Europe with cataracts and intraocular inflammation. The cataracts were bilateral in 55.6%, unilateral in 44.4%, and progressive in 46.4% of patients. Granulomatous anterior uveitis was found in all infants. Presence of S. ixodetis was supported by PCR (positive in 89.3% of eyes tested), transmission electron microscopy (positive in 90% of eyes tested), or culture of aspirated lens material (positive in 87.5% of eyes tested). Treatment with macrolide antimicrobial drugs, corticosteroids, and lensectomy appeared to be effective. Two patients had a recurrence of the uveitis after lens extraction and needed prolonged treatment. To increase awareness of S. ixodetis, we suggest its inclusion with the organisms of the TORCH acronym.
据报道，嗜蜱螺旋体可导致婴儿出现罕见的白内障与葡萄膜炎合并症。通过对现有文献及其他未发表病例的回顾性分析，我们确定了来自欧洲8个国家的18名婴儿的28只眼睛患有白内障和眼内炎症。白内障在55.6%的患者中为双侧，44.4%为单侧，46.4%呈进行性发展。所有婴儿均发现有肉芽肿性前葡萄膜炎。通过聚合酶链反应（89.3%检测的眼睛呈阳性）、透射电子显微镜检查（90%检测的眼睛呈阳性）或吸出晶状体物质培养（87.5%检测的眼睛呈阳性）证实了嗜蜱螺旋体的存在。使用大环内酯类抗菌药物、皮质类固醇和晶状体切除术进行治疗似乎有效。两名患者在晶状体摘除术后葡萄膜炎复发，需要长期治疗。为提高对嗜蜱螺旋体的认识，我们建议将其纳入TORCH首字母缩略词所代表的病原体中。
