Li Baobao, Wang Jingji, Wang Bin, Wang Xuncui, Zhu Guoqi, Yang Shaojie
Center for Xin'an Medicine and Modernization of Traditional Chinese Medicine of IHM, Key Laboratory of Molecular Biology (Brain diseases), Anhui University of Chinese Medicine, Hefei, 230012, China; Key Laboratory of Xin'an Medicine, The Ministry of Education, Anhui University of Chinese Medicine, Hefei, 230038, China.
The Second Affiliated Hospital of Anhui University of Chinese Medicine, Hefei, 230061, China.
J Ethnopharmacol. 2025 Jun 26;350:120052. doi: 10.1016/j.jep.2025.120052. Epub 2025 May 27.
Polygonatum is a genus within the family Asparagaceae, widely utilized in traditional medicine. Modern studies have substantiated its pharmacological properties, including anti-aging, neuroprotective, immunomodulatory, anti-diabetic, memory-enhancing, anti-inflammatory, and antioxidant effects. Recently, research on Polygonatum in the neuropsychiatric disorders has increased.
This review aims to provide a comprehensive summary of the medicinal plants and prescriptions from Polygonatum in the neuropsychiatric disorders, chemical components, and pharmacological and toxicological research evidence. It provides an extensive reference for the development of Polygonatum medicinal resources and the advancement of research in neuropsychiatric therapeutics.
A comprehensive literature review was conducted using databases such as PubMed, Science Direct, Web of Science, and CNKI, along with sources like the "Chinese Pharmacopoeia" and other herbal medicine books. Keywords such as "Polygonatum", "neurological disorders", "Alzheimer's disease", and "toxicity" were employed to collate evidence of the traditional therapeutic effects, phytochemistry, pharmacology, and toxicology of Polygonatum species.
The genus Polygonatum comprises 86 species, of which 36 are medicinally utilized. There are 47 prescriptions containing Polygonatum species relevant to the prevention and treatment of neuropsychiatric disorders. A total of 427 compounds have been isolated from this genus, including 83 polysaccharides, 176 saponins, 83 flavonoids, 47 alkaloids, and 38 other components. The pharmacological actions of Polygonatum herbs include anti-aging, neuroprotection, sleep promotion, immune modulation, anti-fatigue, anti-diabetic, memory enhancement, anti-inflammatory, and antioxidant effects, showing improvement in conditions such as Alzheimer's disease, Parkinson's disease, vascular dementia, depression, sleep disorders, and post-traumatic stress disorder, with no apparent toxicity.
Polygonatum herbs hold potential as therapeutic agents for neuropsychiatric disorders, presenting significant implications for the development of neurological drugs and the utilization of medicinal plant resources.
黄精属是天门冬科的一个属，在传统医学中广泛应用。现代研究已证实其药理特性，包括抗衰老、神经保护、免疫调节、抗糖尿病、增强记忆、抗炎和抗氧化作用。最近，关于黄精在神经精神疾病方面的研究有所增加。
本综述旨在全面总结黄精属植物在神经精神疾病中的药用植物、方剂、化学成分以及药理和毒理学研究证据。为黄精药用资源的开发和神经精神治疗学研究的进展提供广泛的参考。
使用PubMed、Science Direct、Web of Science和CNKI等数据库，以及《中国药典》和其他草药书籍等资源进行全面的文献综述。采用“黄精”“神经系统疾病”“阿尔茨海默病”和“毒性”等关键词来整理黄精属植物传统治疗作用、植物化学、药理学和毒理学的证据。
黄精属包括86个物种，其中36个有药用价值。有47个含有黄精属植物的方剂与神经精神疾病的防治相关。从该属中总共分离出427种化合物，包括83种多糖、176种皂苷、83种黄酮类、47种生物碱和38种其他成分。黄精属草药的药理作用包括抗衰老、神经保护、促进睡眠、免疫调节、抗疲劳、抗糖尿病、增强记忆、抗炎和抗氧化作用，对阿尔茨海默病、帕金森病、血管性痴呆、抑郁症、睡眠障碍和创伤后应激障碍等病症有改善作用，且无明显毒性。
黄精属草药具有作为神经精神疾病治疗药物的潜力，对神经药物的开发和药用植物资源的利用具有重要意义。
