Getrajdman G I, O'Toole K, Logerfo P, Laffey K J, Martin E C
Invest Radiol. 1985 Jul;20(4):393-8. doi: 10.1097/00004424-198507000-00010.
Catheter sclerosis of 56 rabbit gallbladders was attempted at laparotomy. The proximal cystic duct was occluded with a hemoclip and transcatheter administration of six different sclerosing agents and a saline control was performed. Eight animals were used for each agent, three being sacrificed after two weeks and the remainder after six weeks. Hot contrast and sotradecol were comparable with saline in their lack of effect on gallbladder mucosa. Alcohol alone, tetracycline, methylcyanoacrylate and alcohol plus trifluoroacetic acid were successful at two weeks in denuding the gallbladder epithelium and promoting fibrosis of the gallbladder wall. After six weeks, evidence of mucosal regeneration was present with all agents, and the epithelium appeared to have grown back from the occluded cystic duct. Late regeneration has not been previously reported and its significance when considering the application of the technique to the human gallbladder is discussed.
在剖腹手术中尝试对56只兔胆囊进行导管硬化。用血管夹闭塞胆囊近端胆管，并经导管给予六种不同的硬化剂及生理盐水作为对照。每种药剂使用八只动物，其中三只在两周后处死，其余在六周后处死。热造影剂和十四烷基硫酸钠对胆囊黏膜无作用，与生理盐水相当。单独使用酒精、四环素、氰基丙烯酸甲酯以及酒精加三氟乙酸在两周时成功剥脱胆囊上皮并促进胆囊壁纤维化。六周后，所有药剂处理的胆囊均有黏膜再生迹象，上皮似乎从闭塞的胆囊管处长回。此前尚未报道过晚期再生情况，本文讨论了在考虑将该技术应用于人体胆囊时晚期再生的意义。
