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兔体内胆囊硬化剂的全身吸收:一项初步研究。

Systemic absorption of gallbladder sclerosing agents in the rabbit. A preliminary study.

作者信息

Remley K B, Cubberley D A, Watanabe A S, Nelson J A, Colby T V

出版信息

Invest Radiol. 1986 May;21(5):396-9. doi: 10.1097/00004424-198605000-00005.

DOI:10.1097/00004424-198605000-00005
PMID:3710740
Abstract

The absorbed levels of ethanol or tetracycline, used as gallbladder sclerosing agents, were measured in the systemic blood circulation of 16 rabbits. The maximal systemic level of ethanol was 46 mg/dl and of tetracycline was 4.6 micrograms/ml after 30 minutes of gallbladder exposure. Comparable serum levels would be considered nontoxic in humans. As a gallbladder sclerosing agent, tetracycline (50 mg/cc) was slightly more effective than 95% ethanol exposed for either 15 or 30 minutes.

摘要

在16只兔子的体循环中测量了用作胆囊硬化剂的乙醇或四环素的吸收水平。暴露胆囊30分钟后,乙醇的最大全身水平为46毫克/分升,四环素的最大全身水平为4.6微克/毫升。在人类中,类似的血清水平被认为是无毒的。作为一种胆囊硬化剂,四环素(50毫克/立方厘米)在暴露15分钟或30分钟时比95%乙醇稍有效。

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