Burgener F A, Gutierrez O H
Invest Radiol. 1985 Jul;20(4):399-402. doi: 10.1097/00004424-198507000-00011.
Diatrizoate, iopamidol and ioxaglate were compared in five normal dogs and in five dogs with presinusoidal cirrhosis and portal hypertension for arterial portography. After selective injection of 40 ml of each contrast agent in iodine concentrations of 320 mg per ml into the superior mesenteric artery, portal vein blood samples were collected in 2-second intervals and the iodine concentrations determined using x-ray energy spectrometry. The highest iodine concentrations in the portal blood were found in both normal portal pressure and portal hypertension with ioxaglate, followed by iopamidol and diatrizoate in this order. Compared with diatrizoate, ioxaglate and iopamidol increased the peak portal blood iodine concentrations 45% and 22%, respectively. The use of ioxaglate in arterial portography should show the portal system at least as well as when a conventional contrast agent is used together with a vasodilator such as tolazoline.
在五只正常犬和五只患有窦性前肝硬化及门静脉高压的犬中，对泛影葡胺、碘帕醇和碘克沙醇进行了动脉门静脉造影比较。在选择性地将每种碘浓度为每毫升320毫克的造影剂40毫升注入肠系膜上动脉后，以2秒的间隔采集门静脉血样，并使用X射线能谱法测定碘浓度。在正常门静脉压力和门静脉高压情况下，门静脉血中碘浓度最高的是碘克沙醇，其次依次是碘帕醇和泛影葡胺。与泛影葡胺相比，碘克沙醇和碘帕醇分别使门静脉血碘浓度峰值提高了45%和22%。在动脉门静脉造影中使用碘克沙醇显示门静脉系统的效果至少应与使用传统造影剂并联合使用血管扩张剂（如妥拉唑啉）时相同。
