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PICH deficiency attenuates the progression of lung adenocarcinoma and disrupts the DNA damage response.

作者信息

Miao Li, Weina Lu, Jiafei Lou, Gaoying Chen, Yinghui Yu, Yinfang Wu, Fei Li, Chao Zhang, Haoyu Tang, Qingyu Weng, Kua Zheng, Shenwei Gao, Yanping Wu, Chen Zhu, Min Zhang, Fangyi Yu, Rui Jin, Zhihua Chen, Xinwei Geng, Songmin Ying, Wen Li

机构信息

Key Laboratory of Respiratory Disease of Zhejiang Province, Department of Respiratory and Critical Care Medicine, Second Affiliated Hospital of Zhejiang University School of Medicine, Hangzhou, Zhejiang, China.

Surgical Intensive Care Unit, Second Affiliated Hospital of Zhejiang University School of Medicine, Hangzhou, Zhejiang, China.

出版信息

Clin Transl Med. 2025 May;15(5):e70349. doi: 10.1002/ctm2.70349.

DOI:10.1002/ctm2.70349
PMID:40442039
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC12122185/
Abstract
摘要
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ee6c/12122185/151ec6a63c35/CTM2-15-e70349-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ee6c/12122185/5f957d06ae6d/CTM2-15-e70349-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ee6c/12122185/8bdfd3b3d95f/CTM2-15-e70349-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ee6c/12122185/151ec6a63c35/CTM2-15-e70349-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ee6c/12122185/5f957d06ae6d/CTM2-15-e70349-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ee6c/12122185/8bdfd3b3d95f/CTM2-15-e70349-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ee6c/12122185/151ec6a63c35/CTM2-15-e70349-g003.jpg

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1
PICH deficiency attenuates the progression of lung adenocarcinoma and disrupts the DNA damage response.PICH缺陷减缓肺腺癌进展并破坏DNA损伤反应。
Clin Transl Med. 2025 May;15(5):e70349. doi: 10.1002/ctm2.70349.
2
PICH deficiency limits the progression of MYC-induced B-cell lymphoma.PICH 缺乏限制了 MYC 诱导的 B 细胞淋巴瘤的进展。
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Loss of PICH Results in Chromosomal Instability, p53 Activation, and Embryonic Lethality.PICH 缺失导致染色体不稳定、p53 激活和胚胎致死。
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PICH: a DNA translocase specially adapted for processing anaphase bridge DNA.PICH：一种专门用于处理后期桥 DNA 的 DNA 转位酶。
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PICH, A protein that maintains genomic stability, can promote tumor growth.PICH，一种维持基因组稳定性的蛋白质，能够促进肿瘤生长。
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本文引用的文献

1
Chromosomal instability as a driver of cancer progression.染色体不稳定性作为癌症进展的驱动因素。
Nat Rev Genet. 2025 Jan;26(1):31-46. doi: 10.1038/s41576-024-00761-7. Epub 2024 Jul 29.
2
DNA damage induces p53-independent apoptosis through ribosome stalling.DNA 损伤通过核糖体停滞诱导 p53 非依赖性细胞凋亡。
Science. 2024 May 17;384(6697):785-792. doi: 10.1126/science.adh7950. Epub 2024 May 16.
3
Integrated analysis of public datasets for the discovery and validation of survival-associated genes in solid tumors.整合公共数据集以发现和验证实体瘤中与生存相关的基因
Innovation (Camb). 2024 Apr 9;5(3):100625. doi: 10.1016/j.xinn.2024.100625. eCollection 2024 May 6.
4
PICH deficiency limits the progression of MYC-induced B-cell lymphoma.PICH 缺乏限制了 MYC 诱导的 B 细胞淋巴瘤的进展。
Blood Cancer J. 2024 Jan 23;14(1):16. doi: 10.1038/s41408-024-00979-y.
5
ERCC6L facilitates the onset of mammary neoplasia and promotes the high malignance of breast cancer by accelerating the cell cycle.ERCC6L 通过加速细胞周期促进乳腺肿瘤的发生并促进乳腺癌的高恶性。
J Exp Clin Cancer Res. 2023 Sep 4;42(1):227. doi: 10.1186/s13046-023-02806-x.
6
The global burden of lung cancer: current status and future trends.全球肺癌负担：现状与未来趋势。
Nat Rev Clin Oncol. 2023 Sep;20(9):624-639. doi: 10.1038/s41571-023-00798-3. Epub 2023 Jul 21.
7
UALCAN: An update to the integrated cancer data analysis platform.UALCAN：一个集成癌症数据分析平台的更新。
Neoplasia. 2022 Mar;25:18-27. doi: 10.1016/j.neo.2022.01.001. Epub 2022 Jan 22.
8
Nanog maintains stemness of Lkb1-deficient lung adenocarcinoma and prevents gastric differentiation.Nanog 维持 Lkb1 缺陷型肺腺癌的干性并阻止其向胃分化。
EMBO Mol Med. 2021 Mar 5;13(3):e12627. doi: 10.15252/emmm.202012627. Epub 2021 Jan 13.
9
Visualizing and interpreting cancer genomics data via the Xena platform.通过Xena平台可视化和解读癌症基因组学数据。
Nat Biotechnol. 2020 Jun;38(6):675-678. doi: 10.1038/s41587-020-0546-8.
10
PICH promotes sister chromatid disjunction and co-operates with topoisomerase II in mitosis.PICH促进姐妹染色单体分离，并在有丝分裂中与拓扑异构酶II协同作用。
Nat Commun. 2015 Dec 8;6:8962. doi: 10.1038/ncomms9962.