Deng Xiangmei, Suito Takuto, Tominaga Makoto, Sokabe Takaaki
Thermal Biology Group, Exploratory Research Center on Life and Living Systems, National Institutes of Natural Sciences, Okazaki, Japan.
Section of Sensory Physiology, Center for Genetic Analysis of Behavior, National Institute for Physiological Sciences, National Institutes of Natural Sciences, Okazaki, Japan.
Commun Biol. 2025 May 29;8(1):765. doi: 10.1038/s42003-025-08154-0.
Sensory inputs of temperature dynamics in the environment are essential for appropriate physiological outputs. The responsiveness of sensory neurons is maintained by functional thermosensor expression. However, the mechanism by which their expression is regulated is unclear. In this study, we identify a monoacylglycerol acyltransferase-coding gene named bishu-1 that contributes to maintaining the responsiveness of cool temperature sensing neurons in Drosophila. bishu-1 mutation leads to abnormal thermal avoidance in a cool temperature range. Cooling-induced responses in dorsal organ cool cells are weakened by the absence of bishu-1, and this is associated with reduced transcription of the ionotropic receptors IR25a and IR21a and a transcription factor broad. Our findings unveil a novel link between lipid metabolism and thermosensor function, thus providing new insights into mechanisms underlying the appropriate maintenance of sensory inputs.
环境中温度动态的感觉输入对于适当的生理输出至关重要。感觉神经元的反应性由功能性热传感器表达维持。然而，其表达的调控机制尚不清楚。在本研究中，我们鉴定出一个名为bishu-1的单酰甘油酰基转移酶编码基因，它有助于维持果蝇中冷温度感应神经元的反应性。bishu-1突变导致在冷温度范围内出现异常的热回避行为。由于bishu-1的缺失，背器官冷细胞中冷却诱导的反应减弱，这与离子otropic受体IR25a和IR21a以及转录因子broad的转录减少有关。我们的研究结果揭示了脂质代谢与热传感器功能之间的新联系，从而为感觉输入适当维持的潜在机制提供了新的见解。
