来自……果实的七种抗炎二芳基庚烷类-吲哚生物碱杂合物
Seven Anti-Inflammatory Diarylheptanoid-Indole Alkaloid Hybrids from the Fruits of .
作者信息
Yu Shu-Fei, Zhao Jin-Na, Li Bo, Ding Yan-Jun, Chen Lu, Wu Zhi-Hang, Wang Jin-Hui, Wang Li-Bo
机构信息
Department of Medicinal Chemistry and Natural Medicine Chemistry, College of Pharmacy, Harbin Medical University, Baojian Road 157, Nangang District, Harbin, 150081, P. R. China.
出版信息
Org Lett. 2025 Jun 13;27(23):6094-6098. doi: 10.1021/acs.orglett.5c01654. Epub 2025 May 30.
Seven novel diarylheptanoid-indole hybrid alkaloids (-) were isolated and characterized from the fruits of . Their structures were elucidated through a combination of spectroscopic analyses and quantum chemical calculations, with a plausible biosynthetic pathway proposed. Biological evaluation demonstrated that compounds - and exhibited comparable or superior anti-inflammatory activity to dexamethasone in suppressing the release of NO, IL-6, and TNF-α in LPS/IFN-γ-activated RAW264.7 murine macrophages.
从……的果实中分离并鉴定出七种新型二芳基庚烷-吲哚杂合生物碱（-）。通过光谱分析和量子化学计算相结合的方法阐明了它们的结构，并提出了一条合理的生物合成途径。生物学评价表明，化合物-和在抑制LPS/IFN-γ激活的RAW264.7小鼠巨噬细胞中NO、IL-6和TNF-α的释放方面表现出与地塞米松相当或更强的抗炎活性。
Zotero 插件