山梨双丙氨酸A和B，两种来自深海来源的[6,5,6]杂合山梨醇类生物碱，与海绵来源的 共同培养。 （原文中“sp.”指代不明，翻译可能存在一定局限性）
Sorbicillalanines A and B, Two [6,5,6] Hybrid-Sorbicillinoid Alkaloids from Deep-Sea-Derived sp. Co-Cultured with Sponge-Derived sp.
作者信息
Pang Xiaoyan, Ren Xue, Chen Weihao, Yang Bin, Zhou Xuefeng, Tian Xinpeng, Guo Peng, Wang Junfeng, Liu Yonghong
机构信息
Guangdong Key Laboratory of Marine Materia Medica/State Key Laboratory of Tropical Oceanography, South China Sea Institute of Oceanology, Chinese Academy of Sciences, Guangzhou 510301, China.
Capital Institute of Pediatrics, Beijing 100020, China.
出版信息
Org Lett. 2025 Jun 13;27(23):6042-6046. doi: 10.1021/acs.orglett.5c01609. Epub 2025 May 29.
Sorbicillalanines A () and B (), two unusual hybrid-sorbicillinoid alkaloids, were isolated from sp. co-cultured with sp. Their structures containing absolute configurations were determined by detailed spectroscopic analysis and ECD and NMR calculations. Structurally, and are the first sorbicillinoids characterized by an unprecedented [6,5,6]-fused ring skeleton with a piperidin-2-one ring. A plausible biosynthetic pathway for and was put forward. displayed significant anti-inflammatory activity in LPS-induced RAW 264.7 macrophages.
山梨双环素A（）和B（）是两种不同寻常的杂合山梨双环素类生物碱，从与 属物种共培养的 属物种中分离得到。通过详细的光谱分析以及电子圆二色光谱（ECD）和核磁共振（NMR）计算确定了它们含有绝对构型的结构。在结构上， 和 是首个具有前所未有的[6,5,6]稠环骨架和哌啶-2-酮环的山梨双环素类化合物。提出了一个关于 和 的合理生物合成途径。 在脂多糖诱导的RAW 264.7巨噬细胞中表现出显著的抗炎活性。
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