Pezner R D, Patterson M P, Hill L R, Desai K R, Vora N, Lipsett J A
Int J Radiat Oncol Biol Phys. 1985 Oct;11(10):1765-8. doi: 10.1016/0360-3016(85)90029-x.
Breast edema was evaluated in 45 patients with Stage I or II breast cancer (including two with simultaneous, bilateral disease), who were treated by breast-preserving treatment approaches. Multiple variable statistical analysis revealed that bra cup size was the only factor significantly related to the appearance of breast edema. Breast edema occurred in 3 of 20 breasts (15%) with bra cup size A or B, as compared to 13 of 27 breasts (48%) with bra cup size C, D or DD(p less than 0.03). Breast edema was more likely to occur in patients who underwent full axillary dissection as compared to those who underwent axillary sampling or no axillary surgery. This observation, however, was not statistically significant. Neither the radiation therapy parameters nor the use of adjuvant chemotherapy were found to be related to the development of breast edema. Breast edema appears to be a transient phenomenon observed most frequently in the first year after the end of irradiation. It was observed much less frequently in those patients evaluated over 1 year following the end of radiation therapy.
对45例采用保乳治疗方法的Ⅰ期或Ⅱ期乳腺癌患者（包括2例同时双侧患病者）的乳腺水肿情况进行了评估。多变量统计分析显示，胸罩罩杯尺寸是与乳腺水肿出现显著相关的唯一因素。胸罩罩杯尺寸为A或B的20个乳房中有3个（15%）出现乳腺水肿，而胸罩罩杯尺寸为C、D或DD的27个乳房中有13个（48%）出现乳腺水肿（p小于0.03）。与接受腋窝采样或未进行腋窝手术的患者相比，接受全腋窝清扫术的患者更易发生乳腺水肿。然而，这一观察结果无统计学意义。未发现放疗参数及辅助化疗的使用与乳腺水肿的发生有关。乳腺水肿似乎是一种在放疗结束后第一年最常出现的短暂现象。在放疗结束1年以上接受评估的患者中，观察到的乳腺水肿情况要少得多。
