病例报告：急性甲型肝炎病毒感染伴直接抗人球蛋白试验阴性的自身免疫性溶血性贫血及α地中海贫血特征
Case Report: Acute hepatitis A virus infection presenting with direct antiglobulin test-negative autoimmune hemolytic anemia and α-thalassemia trait.
作者信息
Debbabi Habiba, Chakroun Eya, Hassine Hajer, Kchir Hela, Cherif Dhouha, Yacoub Haythem, Maamouri Nadia
机构信息
Gastroenterology 'B' Department, La Rabta University Hospital Center, Tunis, Tunis, Tunisia.
Hematology Department and Blood Bank, La Rabta University Hospital Center, Tunis, Tunis, Tunisia.
出版信息
F1000Res. 2025 Apr 15;13:1224. doi: 10.12688/f1000research.156586.2. eCollection 2024.
Reports from the literature have discussed patients presenting Hepatitis A virus infection with hemolytic anemia, specifically with glucose-6-phosphate dehydrogenase deficiency. However, autoimmune hemolytic anemia (AIHA) has been rarely reported. We present a challenging case of Coombs-negative hemolytic anemia as initial manifestation of hepatitis A virus infection in a silent carrier of α-thalassemia.
文献报道曾讨论过感染甲型肝炎病毒且伴有溶血性贫血的患者，特别是伴有葡萄糖 - 6 - 磷酸脱氢酶缺乏症的患者。然而，自身免疫性溶血性贫血（AIHA）的报道却很少。我们报告了一例具有挑战性的病例，一名α地中海贫血隐性携带者以库姆斯阴性溶血性贫血作为甲型肝炎病毒感染的初始表现。
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