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Case Report: Acute hepatitis A virus infection presenting with direct antiglobulin test-negative autoimmune hemolytic anemia and α-thalassemia trait.病例报告：急性甲型肝炎病毒感染伴直接抗人球蛋白试验阴性的自身免疫性溶血性贫血及α地中海贫血特征
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本文引用的文献

1
Acute Hepatitis A Causing Severe Hemolysis and Renal Failure in Undiagnosed Glucose-6-Phosphate Dehydrogenase Deficient Patient: A Case Report and Review of the Literature.急性甲型肝炎在未确诊的葡萄糖-6-磷酸脱氢酶缺乏患者中导致严重溶血和肾衰竭：一例报告及文献复习
Case Reports Hepatol. 2021 Jun 3;2021:5512883. doi: 10.1155/2021/5512883. eCollection 2021.
2
Update on the management and treatment of viral hepatitis.病毒性肝炎的管理和治疗进展。
World J Gastroenterol. 2021 Jun 21;27(23):3249-3261. doi: 10.3748/wjg.v27.i23.3249.
3
Diagnosis and Management of Autoimmune Hemolytic Anemia in Patients with Liver and Bowel Disorders.肝脏和肠道疾病患者自身免疫性溶血性贫血的诊断与管理
J Clin Med. 2021 Jan 22;10(3):423. doi: 10.3390/jcm10030423.
4
Hepatitis A Virus-induced Severe Hemolysis Complicated by Severe Glucose-6-Phosphate Dehydrogenase Deficiency.甲型肝炎病毒诱发的严重溶血并伴有严重葡萄糖-6-磷酸脱氢酶缺乏症。
Indian J Crit Care Med. 2018 Sep;22(9):670-673. doi: 10.4103/ijccm.IJCCM_260_18.
5
Direct Antiglobulin Test-Negative Autoimmune Hemolytic Anemia.直接抗人球蛋白试验阴性的自身免疫性溶血性贫血
Acta Haematol. 2018;140(1):18-19. doi: 10.1159/000489253. Epub 2018 Jul 13.
6
Immune Thrombocytopenic Purpura and Hemolytic Anemia Secondary to Hepatitis A.甲型肝炎继发免疫性血小板减少性紫癜和溶血性贫血
Int J Hematol Oncol Stem Cell Res. 2017 Apr 1;11(2):89-91.
7
The diagnosis and management of primary autoimmune haemolytic anaemia.原发性自身免疫性溶血性贫血的诊断与管理
Br J Haematol. 2017 Feb;176(3):395-411. doi: 10.1111/bjh.14478. Epub 2016 Dec 22.
8
Pure red-cell aplasia and autoimmune hemolytic anemia in a patient with acute hepatitis A.一名甲型急性肝炎患者并发纯红细胞再生障碍性贫血和自身免疫性溶血性贫血。
Clin Mol Hepatol. 2014 Jun;20(2):204-7. doi: 10.3350/cmh.2014.20.2.204. Epub 2014 Jun 30.
9
Direct antiglobulin ("Coombs") test-negative autoimmune hemolytic anemia: a review.直接抗球蛋白（“库姆斯”）试验阴性的自身免疫性溶血性贫血：综述
Blood Cells Mol Dis. 2014 Apr;52(4):152-60. doi: 10.1016/j.bcmd.2013.12.003. Epub 2014 Jan 9.
10
How I treat thalassemia.我如何治疗地中海贫血症。
Blood. 2011 Sep 29;118(13):3479-88. doi: 10.1182/blood-2010-08-300335. Epub 2011 Aug 2.

病例报告：急性甲型肝炎病毒感染伴直接抗人球蛋白试验阴性的自身免疫性溶血性贫血及α地中海贫血特征

Case Report: Acute hepatitis A virus infection presenting with direct antiglobulin test-negative autoimmune hemolytic anemia and α-thalassemia trait.

作者信息

Debbabi Habiba, Chakroun Eya, Hassine Hajer, Kchir Hela, Cherif Dhouha, Yacoub Haythem, Maamouri Nadia

机构信息

Gastroenterology 'B' Department, La Rabta University Hospital Center, Tunis, Tunis, Tunisia.

Hematology Department and Blood Bank, La Rabta University Hospital Center, Tunis, Tunis, Tunisia.

出版信息

F1000Res. 2025 Apr 15;13:1224. doi: 10.12688/f1000research.156586.2. eCollection 2024.

DOI:10.12688/f1000research.156586.2
PMID:40443430
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC12120424/
Abstract

Reports from the literature have discussed patients presenting Hepatitis A virus infection with hemolytic anemia, specifically with glucose-6-phosphate dehydrogenase deficiency. However, autoimmune hemolytic anemia (AIHA) has been rarely reported. We present a challenging case of Coombs-negative hemolytic anemia as initial manifestation of hepatitis A virus infection in a silent carrier of α-thalassemia.

摘要

文献报道曾讨论过感染甲型肝炎病毒且伴有溶血性贫血的患者，特别是伴有葡萄糖 - 6 - 磷酸脱氢酶缺乏症的患者。然而，自身免疫性溶血性贫血（AIHA）的报道却很少。我们报告了一例具有挑战性的病例，一名α地中海贫血隐性携带者以库姆斯阴性溶血性贫血作为甲型肝炎病毒感染的初始表现。