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司库奇尤单抗治疗泛发性脓疱型银屑病合并Hallopeau连续性肢端皮炎：一例报告及机制探讨

Spesolimab in generalized pustular psoriasis complicated by acrodermatitis continua of Hallopeau: a case report and mechanistic insights.

作者信息

Hou Xin-Yi, Xiao Hai-Lu, Wang Jing-Yu, Zhang Jin, Ren Bo, Niu Chu-Chu, Liu Fei-Fei, Lu Bin

机构信息

Department of Dermatology, Affiliated Hospital of Jining Medical University, Jining, Shandong, China.

School of Clinical Medicine, Jining Medical University, Jining, Shandong, China.

出版信息

Front Immunol. 2025 May 15;16:1563553. doi: 10.3389/fimmu.2025.1563553. eCollection 2025.

DOI:10.3389/fimmu.2025.1563553
PMID:40443665
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC12119614/
Abstract

A 62-year-old Chinese woman presented to the hospital for help with generalized pustular psoriasis (GPP) and acrodermatitis continua of Hallopeau (ACH). While conventional treatments failed to achieve significant improvement, the patient received two doses of spesolimab, and the effect was remarkable. No adverse reactions were observed in the follow-up period.

摘要

一名62岁的中国女性因泛发性脓疱型银屑病（GPP）和Hallopeau连续性肢端皮炎（ACH）前往医院寻求帮助。尽管传统治疗未能取得显著改善，但该患者接受了两剂司帕索利单抗，效果显著。随访期间未观察到不良反应。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/57c1/12119614/65b0d2c813d5/fimmu-16-1563553-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/57c1/12119614/7087c777bde0/fimmu-16-1563553-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/57c1/12119614/2d293233ff91/fimmu-16-1563553-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/57c1/12119614/65b0d2c813d5/fimmu-16-1563553-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/57c1/12119614/7087c777bde0/fimmu-16-1563553-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/57c1/12119614/2d293233ff91/fimmu-16-1563553-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/57c1/12119614/65b0d2c813d5/fimmu-16-1563553-g003.jpg

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本文引用的文献

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Pustular Eruption following COVID-19 Vaccination: A Narrative Case-Based Review.新型冠状病毒肺炎疫苗接种后出现的脓疱性皮疹：基于病例的叙述性综述
Vaccines (Basel). 2023 Jul 29;11(8):1298. doi: 10.3390/vaccines11081298.
2
Commentary on a Clinical Trial of Spesolimab, a Humanized Anti-interleukin-36 Receptor Monoclonal Antibody, in Generalized Pustular Psoriasis.关于人源化抗白细胞介素-36受体单克隆抗体斯佩索利单抗治疗泛发性脓疱型银屑病的一项临床试验的评论
Dermatol Ther (Heidelb). 2022 Dec;12(12):2627-2635. doi: 10.1007/s13555-022-00830-x. Epub 2022 Oct 8.
3
Safety and tolerability of spesolimab in patients with ulcerative colitis.
斯帕利单抗治疗溃疡性结肠炎患者的安全性和耐受性。
Expert Opin Drug Saf. 2023 Feb;22(2):141-152. doi: 10.1080/14740338.2022.2103536. Epub 2022 Jul 31.
4
Pathophysiology of Generalized Pustular Psoriasis.全身性脓疱型银屑病的发病机制。
Am J Clin Dermatol. 2022 Jan;23(Suppl 1):13-19. doi: 10.1007/s40257-021-00655-y. Epub 2022 Jan 21.
5
Pustular Psoriasis: A Narrative Review of Recent Developments in Pathophysiology and Therapeutic Options.脓疱型银屑病：病理生理学与治疗选择最新进展的叙述性综述
Dermatol Ther (Heidelb). 2021 Dec;11(6):1917-1929. doi: 10.1007/s13555-021-00612-x. Epub 2021 Oct 9.
6
An update on genetic basis of generalized pustular psoriasis (Review).泛发性脓疱型银屑病的遗传学基础研究进展（综述）。
Int J Mol Med. 2021 Jun;47(6). doi: 10.3892/ijmm.2021.4951. Epub 2021 May 6.
7
Study protocol of the global Effisayil 1 Phase II, multicentre, randomised, double-blind, placebo-controlled trial of spesolimab in patients with generalized pustular psoriasis presenting with an acute flare.全球 Effisayil 1 期 II 期、多中心、随机、双盲、安慰剂对照研究方案，评估 spesolimab 在伴有急性发作的泛发性脓疱性银屑病患者中的疗效。
BMJ Open. 2021 Mar 30;11(3):e043666. doi: 10.1136/bmjopen-2020-043666.
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Pustular Psoriasis: The Dawn of a New Era.脓疱型银屑病：新时代的曙光。
Acta Derm Venereol. 2020 Jan 30;100(3):adv00034. doi: 10.2340/00015555-3388.
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