Dermatology Unit, University of Rome "Tor Vergata", Rome, Italy.
Dermatol Ther. 2019 May;32(3):e12899. doi: 10.1111/dth.12899. Epub 2019 Apr 29.
Acrodermatitis continua of Hallopeau (ACH) is a rare pustular psoriasis variant refractory to many conventional treatments. We report the successful treatment with secukinumab of a patient with a long history of ACH with marked onychodystrophy with frank pustulosis on the nail bed and with accompanying arthritis. Blockade of the IL-17 receptor A has shown promise in the treatment of psoriatic erythroderma and generalized pustular psoriasis not responsive to conventional treatment. A rapid response was observed in our patient, in both skin lesions and arthritic symptoms, underlining the ability of secukinumab to improve symptoms beyond those of plaque psoriasis.
Hallopeau 连续性肢端皮炎（ACH）是一种罕见的脓疱性银屑病变种，对许多传统治疗方法有抗药性。我们报告了一例 ACH 病史长、伴有明显甲营养不良、甲床有明显脓疱病且伴有关节炎的患者，使用司库奇尤单抗治疗获得成功。IL-17 受体 A 阻断剂在治疗对常规治疗无反应的银屑病红皮病和泛发性脓疱性银屑病方面显示出良好的疗效。我们的患者在皮肤病变和关节炎症状方面均迅速得到改善，这突出了司库奇尤单抗除改善斑块状银屑病外，还能改善症状的能力。
