Putri Restika E, Zakiyah Neily, Puspita Falerina, Alfian Sofa D
Department of Pharmacology and Clinical Pharmacy, Faculty of Pharmacy, Universitas Padjadjaran, Sumedang, Indonesia.
Center of Excellence for Pharmaceutical Care Innovation, Universitas Padjadjaran, Sumedang, Indonesia.
Patient Prefer Adherence. 2025 May 25;19:1523-1537. doi: 10.2147/PPA.S514046. eCollection 2025.
Nonadherence to medication is common during pregnancy, as pregnant women often have concerns about the safety of the medications they are taking. This study aimed to assess medication adherence levels among pregnant women for various medications and to identify factors associated with nonadherence.
We conducted an observational cross-sectional study among pregnant women who had used at least one medication in the past month at a hospital in Bandung City, West Java, Indonesia. Medication adherence was assessed using the Medication Adherence Report Scale (MARS-5), while medication beliefs were measured with the Beliefs about Medicine Questionnaire (BMQ). Binary logistic regression was used to evaluate the association between medication beliefs, sociodemographic factors, and medication adherence. Odds ratios (ORs) with 95% confidence intervals (CIs) were reported.
Among the 235 pregnant women, the adherence levels for each group were as follows: 60.5% for the pregnancy supplements and hormones group, 53.8% for the chronic condition medicines group, 100% for the antibiotics group, and 46.2% for the symptomatic medicines group. A small sample size led to perfect adherence in the antibiotics group. Factors associated with non-adherence were higher harm beliefs (OR 1.20, 95% CI 1.02-1.40) and negative beliefs (OR 2.42, 95% CI 1.09-5.33) for the pregnancy supplements and hormones group; negative beliefs (OR 5.16, 95% CI 1.44-18.4) for the chronic medication group; not being in the first pregnancy (23.92, 95% CI 1.08-530.55) and the use of more than two types of medicines (OR 29.55, 95% CI 1.06-825.08) for symptomatic medications.
Medication adherence during pregnancy, especially to chronic condition medications, remains low, highlighting the urgent need for intervention. One of the main factors associated with this low adherence during pregnancy is negative beliefs about medications. Tailored counselling on medication use during pregnancy is necessary to address these misconceptions and improve medication adherence in pregnancy.
孕期不遵医嘱服药的情况很常见，因为孕妇通常担心所服用药物的安全性。本研究旨在评估孕妇对各类药物的服药依从性水平，并确定与不依从相关的因素。
我们在印度尼西亚西爪哇省万隆市一家医院对过去一个月内至少使用过一种药物的孕妇进行了一项观察性横断面研究。使用药物依从性报告量表（MARS - 5）评估服药依从性，同时用药物信念问卷（BMQ）测量药物信念。采用二元逻辑回归评估药物信念、社会人口学因素与服药依从性之间的关联。报告了具有95%置信区间（CI）的比值比（OR）。
在235名孕妇中，各组的依从性水平如下：孕期补充剂和激素组为60.5%，慢性病药物组为53.8%，抗生素组为100%，对症药物组为46.2%。样本量较小导致抗生素组出现完全依从的情况。与不依从相关的因素包括：孕期补充剂和激素组中更高的危害信念（OR 1.20，95% CI 1.02 - 1.40）和负面信念（OR 2.42，95% CI 1.09 - 5.33）；慢性病药物组中的负面信念（OR 5.16，95% CI 1.44 - 18.4）；对症药物组中不是初孕（OR 23.92，95% CI 1.08 - 530.55）以及使用超过两种类型的药物（OR 29.55，95% CI 1.06 - 825.08）。
孕期服药依从性，尤其是对慢性病药物的依从性仍然很低，这凸显了进行干预的迫切需求。孕期这种低依从性的主要相关因素之一是对药物的负面信念。有必要针对孕期用药进行个性化咨询，以消除这些误解并提高孕期服药依从性。
