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孕期患有慢性病的女性在药物使用信念方面的差异:一项跨国、横断面、基于网络的研究。

Differences in medication beliefs between pregnant women using medication, or not, for chronic diseases: a cross-sectional, multinational, web-based study.

机构信息

Clinical Pharmacy and Pharmacology, University Medical Centre Groningen, University of Groningen, Groningen, The Netherlands.

Pharmaco Epidemiology and Drug Safety Research Group, Department of Pharmacy, University of Oslo, Oslo, Norway.

出版信息

BMJ Open. 2020 Feb 5;10(2):e034529. doi: 10.1136/bmjopen-2019-034529.

Abstract

OBJECTIVES

To assess whether medication beliefs differ between women who use or not use medication for their somatic chronic diseases during pregnancy and whether this association varies across diseases.

DESIGN

Cross-sectional web-based survey.

SETTING

Multinational study in Europe.

PARTICIPANTS

Pregnant women or women with children less than 1 year old from European countries and with asthma, allergy, cardiovascular, rheumatic diseases, diabetes, epilepsy and/or inflammatory bowel diseases (IBD).

PRIMARY AND SECONDARY OUTCOME MEASURE

Differences in scores of the (BMQ).

RESULTS

In total, 1219 women were included (ranging from 736 for allergy to 49 for IBD). Women using medication for their chronic disease (n=770; 63%) had higher scores on the BMQ subscales (16.6 vs 12.1, p<0.001) and (16.2 vs 15.4, p<0.001), and lower values on the subscales (12.5 vs 13.1; p=0.005) and (9.8 vs 10.7, p<0.001) than women not using medication. No significant differences were shown for the subscale (12.5 vs 12.3, p=0.484). Beliefs varied somewhat across diseases but in general more positive beliefs among women using medication were shown. Epilepsy was the disease where less differences were observed between women using and not using medication.

CONCLUSION

Women's beliefs were associated with medication use during pregnancy with only small differences across the diseases. Knowing pregnant women's beliefs could help identify women who are reluctant to use medication and could guide counselling to support making well-informed treatment decisions.

摘要

目的

评估在怀孕期间使用或不使用药物治疗躯体慢性疾病的女性之间的药物信念是否存在差异,以及这种关联是否因疾病而异。

设计

基于网络的横断面研究。

地点

欧洲多国研究。

参与者

来自欧洲国家的患有哮喘、过敏、心血管、风湿性疾病、糖尿病、癫痫和/或炎症性肠病(IBD)的孕妇或有 1 岁以下子女的女性。

主要和次要结局测量

(BMQ)得分的差异。

结果

共纳入 1219 名女性(范围从过敏的 736 名到 IBD 的 49 名)。患有慢性疾病并使用药物治疗的女性(n=770;63%)在 BMQ 子量表 (16.6 比 12.1,p<0.001)和 (16.2 比 15.4,p<0.001)上的得分较高,而在子量表 (12.5 比 13.1;p=0.005)和 (9.8 比 10.7,p<0.001)上的得分较低。在 子量表上没有显示出显著差异(12.5 比 12.3,p=0.484)。信念在不同疾病之间存在一定差异,但总体而言,使用药物的女性表现出更积极的信念。在使用和不使用药物的女性之间,癫痫的差异最小。

结论

女性的信念与怀孕期间的药物使用有关,但不同疾病之间的差异很小。了解孕妇的信念可以帮助识别不愿意使用药物的女性,并可以指导咨询,以支持做出明智的治疗决策。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/eeab/7044950/21bfe48a078c/bmjopen-2019-034529f01.jpg

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