Haghollahi Shahab, Wood Rebecca M, Ould Ismail Abdol Aziz, Ren Bing, Afzal Muhammad Z
Department of Medicine, Dartmouth-Hitchcock Medical Center at Dartmouth Geisel School of Medicine, Hanover, NH 03756, United States.
Department of Pathology and Laboratory Medicine, Dartmouth-Hitchcock Medical Center at Dartmouth Geisel School of Medicine, Hanover, NH 03756, United States.
Oxf Med Case Reports. 2025 May 28;2025(5):omaf062. doi: 10.1093/omcr/omaf062. eCollection 2025 May.
Anastrozole, an aromatase inhibitor (AI), has been used extensively for the treatment of estrogen receptor-positive breast cancer. Autoimmune hepatitis (AIH) is an extremely rare but serious complication of anastrozole treatment.
We present the case of an 81-year-old female who presented with significantly elevated liver function test (LFTs) results 8 months after the initiation of anastrozole for early-stage breast cancer. Serological and liver biopsy findings were consistent with AIH. Discontinuation of anastrozole, along with a short course of steroids, resulted in rapid clinical improvement and normalization of both LFTs and autoantibodies.
Clinicians should be aware of drug-induced AIH as a rare but life-threatening complication of anastrozole and potentially other aromatase inhibitors.
阿那曲唑，一种芳香化酶抑制剂（AI），已被广泛用于治疗雌激素受体阳性乳腺癌。自身免疫性肝炎（AIH）是阿那曲唑治疗极其罕见但严重的并发症。
我们报告一例81岁女性病例，该患者在开始使用阿那曲唑治疗早期乳腺癌8个月后，肝功能检查（LFTs）结果显著升高。血清学和肝脏活检结果与自身免疫性肝炎相符。停用阿那曲唑并短期使用类固醇后，临床症状迅速改善，LFTs和自身抗体均恢复正常。
临床医生应意识到药物性AIH是阿那曲唑以及其他潜在芳香化酶抑制剂罕见但危及生命的并发症。
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