BNC1通过调节CCL20/JAK-STAT轴抑制胃癌的发生和发展。
BNC1 inhibits the development and progression of gastric cancer by regulating the CCL20/JAK-STAT axis.
作者信息
Liu Lixin, Xiong Li, Peng Hong, Deng Qin, Liu Kang, Xia Shusen
机构信息
The Second Department of Gastrointestinal Surgery, The Affiliated Hospital of the North Sichuan Medical College, Nanchong, Sichuan, China.
Institute of Tissue Engineering and Stem Cell, Beijing Anzhen Nanchong Hospital of Capital Medical University, Nanchong Central Hospital, The Second Clinical Medical College of North Sichuan Medical College, Nanchong, Sichuan, China.
出版信息
PeerJ. 2025 May 26;13:e19477. doi: 10.7717/peerj.19477. eCollection 2025.
The role of basonuclin 1 (BNC1), a zinc finger protein-specific transcription factor, in gastric cancer remains unclear. In this study, BNC1 was downregulated in gastric cancer and functioned as a tumor suppressor. Through integrative analyses of transcriptome sequencing and functional assays, C-C motif chemokine ligand 20 (CCL20) was identified as a direct downstream target of BNC1. Overexpression of BNC1 inhibited the proliferation, migration, and invasion of gastric cancer cells both and . Mechanistically, BNC1 suppresses CCL20 expression by binding to its promoter, leading to reduced activation of the JAK-STAT signaling pathway and promoting apoptosis in gastric cancer cells. These findings highlight the pivotal role of BNC1 in gastric cancer progression and suggest that targeting BNC1 and its downstream pathways could serve as a potential therapeutic strategy.
锌指蛋白特异性转录因子巴松纽克林1（BNC1）在胃癌中的作用尚不清楚。在本研究中，BNC1在胃癌中表达下调，并发挥肿瘤抑制作用。通过转录组测序和功能分析的综合分析，C-C基序趋化因子配体20（CCL20）被确定为BNC1的直接下游靶点。BNC1的过表达在体内和体外均抑制胃癌细胞的增殖、迁移和侵袭。机制上，BNC1通过结合CCL20启动子抑制其表达，导致JAK-STAT信号通路激活减少，促进胃癌细胞凋亡。这些发现突出了BNC1在胃癌进展中的关键作用，并表明靶向BNC1及其下游通路可能是一种潜在的治疗策略。
Zotero 插件