Patel Roshniben, Mohan Akhila, Pokharel Kishor, Pardi Maria
Internal Medicine, Saint Agnes Hospital, Baltimore, USA.
Cureus. 2021 May 30;13(5):e15331. doi: 10.7759/cureus.15331. eCollection 2021 May.
Human herpesvirus 6 (HHV-6) manifesting as a central nervous system (CNS) infection (especially meningoencephalitis) is reported as a primary infection in children and from reactivation in immunocompromised patients; however, it has rarely been reported in immunocompetent adults. Latent infections of the CNS can cause a myriad of clinical presentations ranging from a benign, febrile, self-resolving illness to limbic encephalitis, temporal lobe seizures, and neuropsychiatric symptoms such as behavioral disturbances and psychosis. No standard diagnostic criteria or management guidelines exist for this condition. Possible neuroimaging findings include abnormalities in the medial temporal lobe involving the hippocampus and amygdala. We hereby present a case of HHV-6 meningitis in a 48-year-old immunocompetent male presenting without encephalopathic symptoms and normal neuroimaging findings.
人类疱疹病毒6型（HHV-6）表现为中枢神经系统（CNS）感染（尤其是脑膜脑炎），据报道在儿童中为原发性感染，在免疫功能低下的患者中则是由病毒再激活引起；然而，在免疫功能正常的成年人中鲜有报道。中枢神经系统的潜伏感染可导致各种各样的临床表现，从良性、发热性、可自行缓解的疾病到边缘性脑炎、颞叶癫痫以及行为障碍和精神病等神经精神症状。目前尚无针对这种情况的标准诊断标准或管理指南。可能的神经影像学表现包括内侧颞叶累及海马体和杏仁核的异常。我们在此报告一例48岁免疫功能正常男性的HHV-6脑膜炎病例，该患者没有脑病症状，神经影像学检查结果正常。
