Sadrinasab Shayan, Saket Sadaf, Pourmohammadi Nadia, Khosravi Fatemeh, Fakhr Masoud Saadat
School of Medicine, Shahid Beheshti School of Medicine, Tehran, Iran.
Shahid Beheshti University of Medical Science and Health Services, Taleghani Hospital, Tehran, Iran.
Discov Oncol. 2025 May 30;16(1):959. doi: 10.1007/s12672-025-02773-z.
Hepatic tumors, such as hepatocellular carcinoma (HCC) and metastatic liver malignancies, represent a substantial worldwide health concern due to elevated mortality rates and unfavorable prognoses. Notwithstanding progress in surgical, locoregional, and systemic therapy, significant obstacles like as late-stage diagnosis, treatment resistance, and discrepancies in healthcare access still hinder patient outcomes. This study thoroughly analyzes recent breakthroughs in hepatic tumor treatment, including surgical improvements, immunotherapy, targeted medicines, and nanotechnology-based drug delivery systems. The discourse emphasizes minimally invasive methods including laparoscopic and robotic-assisted hepatectomies, the function of immune checkpoint inhibitors, and the promise of nanoparticle-based therapeutics to improve drug administration while reducing systemic toxicity. This study aims to critically assess current hepatic tumor treatments, examining their effectiveness, constraints, and prospective developments. Critical concerns, such as drug resistance, post-treatment recurrence, and the accessibility of innovative medicines in resource-constrained environments, are addressed. The review underscores the significance of personalized medicine, biomarker-guided treatment approaches, and interdisciplinary teamwork in enhancing therapeutic results. Future research seeks to enhance patient survival and quality of life through the integration of developing technology and the refinement of present treatment approaches.
肝肿瘤,如肝细胞癌(HCC)和转移性肝恶性肿瘤,由于死亡率升高和预后不良,在全球范围内引起了广泛的健康关注。尽管在手术、局部区域和全身治疗方面取得了进展,但诸如晚期诊断、治疗耐药性以及医疗服务可及性差异等重大障碍仍然阻碍着患者的治疗效果。本研究全面分析了肝肿瘤治疗的最新突破,包括手术改进、免疫疗法、靶向药物以及基于纳米技术的药物递送系统。论述强调了微创方法,包括腹腔镜和机器人辅助肝切除术、免疫检查点抑制剂的作用,以及基于纳米颗粒的疗法在改善药物给药同时降低全身毒性方面的前景。本研究旨在严格评估当前的肝肿瘤治疗方法,审视其有效性、局限性和未来发展。解决了诸如耐药性、治疗后复发以及资源有限环境中创新药物的可及性等关键问题。该综述强调了个性化医疗、生物标志物指导的治疗方法以及跨学科团队合作在提高治疗效果方面的重要性。未来的研究旨在通过整合新兴技术和完善现有治疗方法来提高患者的生存率和生活质量。