Kuptsova A M, Zefirov A L, Ziyatdinova N I, Mosolov L T, Zefirov T L
Department of Human Health Protection, Kazan (Volga Region) Federal University, Kazan, Russia.
Department of Normal Physiology, Kazan State Medical University, Ministry of Health of the Russian Federation, Kazan, Russia.
Bull Exp Biol Med. 2025 Apr;178(6):707-712. doi: 10.1007/s10517-025-06402-1. Epub 2025 May 30.
The blockade of hyperpolarization-activated currents (I) (10 and 10 M) had a multidirectional effect on the left ventricular developed pressure and the maximum contraction rate of the isolated heart in healthy, sham-operated rats, and rats with experimental acute myocardial infarction (AMI). The duration of isolated heart contraction in the presence of the I blocker at both concentrations decreased in the group of healthy animals and did not change in sham-operated rats and rats with AMI. I blockade increased the duration of isolated heart relaxation in all groups. The duration of the contraction cycle under conditions of I blockade (10 M) increased in sham-operated rats and rats with AMI and decreased in healthy rats. The maximum concentration of the blocker increased the duration of contraction cycle in all experimental groups.
超极化激活电流（I）阻滞剂（10和10 M）对健康、假手术大鼠以及实验性急性心肌梗死（AMI）大鼠的离体心脏左心室舒张末压和最大收缩速率具有多向性影响。在两个浓度的I阻滞剂存在下，健康动物组离体心脏收缩持续时间缩短，假手术大鼠和AMI大鼠的收缩持续时间未改变。I阻滞剂使所有组的离体心脏舒张持续时间增加。在I阻滞剂（10 M）作用下，假手术大鼠和AMI大鼠的收缩周期持续时间增加，健康大鼠的收缩周期持续时间缩短。阻滞剂的最大浓度使所有实验组的收缩周期持续时间增加。
