Department of Human Health Protection, Kazan (Volga region) Federal University, Kazan, Republic of Tatarstan, Russia.
Bull Exp Biol Med. 2024 Jan;176(3):315-320. doi: 10.1007/s10517-024-06015-0. Epub 2024 Feb 12.
We performed a comparative analysis of the effect of α-adrenoreceptor stimulation on the performance of Langendorff-isolated heart from rats with experimental myocardial infarction in the acute stage and sham-operated animals (control). In animals with peracute myocardial infarction, different agonist concentrations (clonidine, 10 and 10 M) produced a multidirectional effect on the left-ventricular developed pressure and speed and time parameters of heart contractility. In control rats, both concentrations of the agonist added to the perfused solution reduced contraction force. Clonidine in a concentration of 10 M reduced HR in both groups and in a concentration of 10 M, it decreased HR in control rats and caused multidirectional changes in rats with myocardial infarction. The coronary flow decreased in all series of experiments.
我们对急性实验性心肌梗死大鼠和假手术动物（对照组）Langendorff 分离心脏的α-肾上腺素受体刺激作用进行了对比分析。在急性心肌梗死动物中，不同激动剂浓度（可乐定，10 和 10 M）对左心室发展压力和速度以及心脏收缩性的时间参数产生了多向作用。在对照组大鼠中，灌流液中加入两种浓度的激动剂均降低了收缩力。可乐定 10 M 浓度降低了两组的心率，而 10 M 浓度降低了对照组大鼠的心率，并导致心肌梗死大鼠的心率发生多向变化。在所有系列实验中，冠脉流量均减少。
