自噬调节药物对皮肤黑色素瘤小鼠模型中与癌症相关成纤维细胞和上皮-间质转化相关标志物表达的影响
The Influence of Autophagy-Modulating Drugs on the Expression of Markers Associated with Cancer-Associated Fibroblasts and Epithelial-Mesenchymal Transition in a Mouse Model of Skin Melanoma.
作者信息
Taskaeva Iu S, Shatruk A Yu, Bgatova N P
机构信息
Research Institute of Clinical and Experimental Lymphology - Branch of Institute of Cytology and Genetics, Siberian Branch of the Russian Academy of Sciences, Novosibirsk, Russia.
出版信息
Bull Exp Biol Med. 2025 Apr;178(6):769-773. doi: 10.1007/s10517-025-06414-x. Epub 2025 May 30.
The expression of cancer-associated fibroblast (CAF) and epithelial-mesenchymal transition marker proteins was assessed in tumor samples of B16 skin melanoma-bearing mice after chloroquine or lithium administration. Chloroquine increased the expression of CAF markers (αSMA and FAP). Hence, chloroquine can contribute to the activation of individual CAF populations in melanoma. In addition, a decrease in the expression of the epithelial marker E-cadherin and an increase in the expression of the mesenchymal marker vimentin were observed after chloroquine administration, which may indicate activation of epithelial-mesenchymal transition processes in the tumor.
在给予氯喹或锂后，对荷B16皮肤黑色素瘤小鼠的肿瘤样本中癌症相关成纤维细胞（CAF）和上皮-间质转化标记蛋白的表达进行了评估。氯喹增加了CAF标记物（αSMA和FAP）的表达。因此，氯喹可促进黑色素瘤中单个CAF群体的激活。此外，给予氯喹后观察到上皮标记物E-钙黏蛋白表达降低，间质标记物波形蛋白表达增加，这可能表明肿瘤中上皮-间质转化过程被激活。
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