Beeren Fenna M M, Harker Mitchell J R, van Bon Arianne C, Groenen Marcel J M, Siersema Peter D
Department of Gastroenterology and Hepatology, Rijnstate Hospital, Arnhem, the Netherlands.
Department of Gastroenterology and Hepatology, Radboud University Medical Center, Nijmegen, the Netherlands.
Endocrinol Diabetes Metab. 2025 Jul;8(4):e70057. doi: 10.1002/edm2.70057.
Endoscopic sutured gastroplasty (ESG) is one of the currently available endoscopic techniques that mimics bariatric surgery. Although the efficacy of ESG on weight loss has repeatedly been demonstrated, its effect on diabetes mellitus type 2 (T2DM) related outcomes is not yet fully clear.
We conducted a systematic review summarising the efficacy of ESG on T2DM. Therefore, PubMed, Embase and Cochrane library were searched for studies evaluating the effect of ESG on T2DM. Both prospective and retrospective studies, published in the English language, were included. Two reviewers independently screened all studies. The primary objectives were T2DM remission rate, decrease in glucose-lowering medication and decrease in HbA1c.
A total of 16 studies including 760 patients with (pre)diabetes were included. Overall, T2DM-related outcomes after ESG improved in 303 of 599 patients (50.6%) (including tapering dose of insulin and/or improvement of HbA1c/fasting glucose). Remission rates of T2DM were reported in 6/11 studies and seen in 89 of 155 (57.0%) patients after 6-36 months.
This systematic review on the efficacy of ESG on T2DM suggests that ESG is able to improve diabetes-related outcomes in approximately half of treated patients, with T2DM remission rates in more than half of them.
内镜缝合胃成形术（ESG）是目前可用的模拟减肥手术的内镜技术之一。尽管ESG对体重减轻的疗效已得到反复证实，但其对2型糖尿病（T2DM）相关结局的影响尚不完全清楚。
我们进行了一项系统评价，总结ESG对T2DM的疗效。因此，检索了PubMed、Embase和Cochrane图书馆，以查找评估ESG对T2DM影响的研究。纳入了以英文发表的前瞻性和回顾性研究。两名评价者独立筛选所有研究。主要目标是T2DM缓解率、降糖药物减少和糖化血红蛋白（HbA1c）降低。
共纳入16项研究，包括760例患有（预）糖尿病的患者。总体而言，599例患者中有303例（50.6%）在ESG后T2DM相关结局得到改善（包括胰岛素剂量逐渐减少和/或HbA1c/空腹血糖改善）。11项研究中有6项报告了T2DM缓解率，6至36个月后，155例患者中有89例（57.0%）出现缓解。
这项关于ESG对T2DM疗效的系统评价表明，ESG能够使大约一半的治疗患者的糖尿病相关结局得到改善，其中一半以上患者的T2DM得到缓解。
