Christensson P I, Erichsen C, Jönsson P E, Stenram U
J Cancer Res Clin Oncol. 1985;110(2):95-7. doi: 10.1007/BF00402718.
In a model of secondary liver cancer in Wistar rats, the incorporation of tracer doses of pyrimidines and 5-fluoropyrimidines into the acid-soluble fraction, RNA and DNA of several normal tissues and of an experimental adenocarcinoma of the colon transplanted to the liver of rat was determined 90 min after infusion of the substances via the gastroduodenal artery. There was a higher incorporation after injection of FUra than after uracil into tumor RNA. There was very little labeling of DNA by FdUrd but a greater labeling of RNA following injection of this substance than following deoxyuridine in all tissues including tumor except in liver, where it was of the same magnitude. All fluoro compounds gave high labeling of the acid-soluble fraction of the kidney and liver. The experiments will be continued with therapeutic doses of the fluoro compounds.
在Wistar大鼠继发性肝癌模型中，通过胃十二指肠动脉注入嘧啶和5-氟嘧啶示踪剂量90分钟后，测定了几种正常组织以及移植到大鼠肝脏的实验性结肠腺癌中，这些物质掺入酸溶性部分、RNA和DNA的情况。注射氟尿嘧啶后肿瘤RNA中的掺入量高于注射尿嘧啶后。氟脱氧尿苷对DNA的标记很少，但注射该物质后RNA的标记在除肝脏外的所有组织（包括肿瘤）中都比注射脱氧尿苷后更高，在肝脏中二者标记程度相同。所有含氟化合物在肾脏和肝脏的酸溶性部分都有很高的标记。将继续进行含氟化合物治疗剂量的实验。
