Chu Che-Sheng, Li Cheng-Ta, Cheng Chih-Ming, Jeng Jia-Shyun, Pan Chih-Chuan, Chen Guan-Wei, Liang Wei-Zhe, Chang Chun-Hung, Fujii Kyoshiro, Kitahata Ryosuke, Noda Yoshihiro
Department of Psychiatry, Kaohsiung Veterans General Hospital, Kaohsiung City, Taiwan; Graduate Institute of Medicine, College of Medicine, Kaohsiung Medical University, Kaohsiung, Taiwan; Center for Geriatrics and Gerontology, Kaohsiung Veterans General Hospital, Kaohsiung City, Taiwan; Non-invasive Neuromodulation Consortium for Mental Disorders, Society of Psychophysiology, Taipei, Taiwan.
Department of Psychiatry, Taipei Veterans General Hospital, Taipei, Taiwan; Division of Psychiatry, School of Medicine, National Yang Ming Chiao Tung University, Taipei, Taiwan; Institute of Brain Science and Brain Research Center, School of Medicine, National Yang Ming Chiao Tung University, Taipei, Taiwan.
Asian J Psychiatr. 2025 Jul;109:104541. doi: 10.1016/j.ajp.2025.104541. Epub 2025 May 20.
This study aimed to identify demographic, clinical, and protocol-related predictors of effectiveness of transcranial magnetic stimulation (TMS) therapy in patients with major depressive disorder (MDD) across Taiwan and Japan.
This retrospective observational study analyzed clinical data collected between September 2023 and August 2024 from patients with MDD treated either repetitive TMS or theta-burst stimulation at two institutes in Taiwan and one in Japan. All patients were assessed using the Hamilton Depression Rating Scale (HAMD) before and after a course of TMS treatment. Variables were assessed for their association with response, remission, and change of HAMD scores from baseline using a multiple logistic and linear regression model.
205 patients (131 Taiwanese and 74 Japanese) were included. The Taiwanese population had a significantly higher percentage of females than the Japanese population (71.0 % vs. 42.5 %). Being married (adjusted odd ratios [aOR] = 2.339) and being employed (aOR = 2.048) were more likely to achieve a response, whereas current alcohol use (aOR = 0.332) was less likely to be associated with response. Additionally, patients who were employed (aOR = 2.183) were more likely to achieve remission, whereas those with a longer duration of illness (aOR = 0.938) and current alcohol use (aOR = 0.310) were less likely to reach remission. Furthermore, being female, being married, being employed, and higher baseline HAMD were more likely having greater reductions in HAMD scores.
This study suggests the specific predictors when predicting the treatment outcome of TMS for MDD patients in Taiwan and Japan.
本研究旨在确定台湾和日本重度抑郁症（MDD）患者经颅磁刺激（TMS）治疗有效性的人口统计学、临床和方案相关预测因素。
这项回顾性观察研究分析了2023年9月至2024年8月期间在台湾的两家机构和日本的一家机构接受重复TMS或theta爆发刺激治疗的MDD患者收集的临床数据。所有患者在一个TMS疗程前后均使用汉密尔顿抑郁量表（HAMD）进行评估。使用多元逻辑回归和线性回归模型评估变量与反应、缓解以及HAMD评分相对于基线的变化之间的关联。
纳入了205名患者（131名台湾患者和74名日本患者）。台湾人群中女性的比例明显高于日本人群（71.0%对42.5%）。已婚（调整后的优势比[aOR]=2.339）和就业（aOR=2.048）的患者更有可能获得反应，而当前饮酒（aOR=0.332）与反应的关联较小。此外，就业的患者（aOR=2.183）更有可能实现缓解，而病程较长（aOR=0.938）和当前饮酒的患者（aOR=0.310）实现缓解的可能性较小。此外，女性、已婚、就业以及较高的基线HAMD更有可能使HAMD评分有更大程度的降低。
本研究提出了预测台湾和日本MDD患者TMS治疗结果时的特定预测因素。
