对抗猫传染性腹膜炎病毒（FIPV）感染的策略：抗病毒药物和疫苗。

Strategies for combating FIPV infection: antiviral agents and vaccines.

作者信息

Gao Fan, Wen Guilan

机构信息

Institute of Veterinary Immunology and Green Drugs, Veterinary Department in College of Animal Science, State Key Laboratory of Green Pesticide, Guizhou University, Guiyang 550025, China.

出版信息

Res Vet Sci. 2025 Aug;192:105709. doi: 10.1016/j.rvsc.2025.105709. Epub 2025 May 27.

DOI:10.1016/j.rvsc.2025.105709

PMID:40446698

Abstract

Feline infectious peritonitis virus (FIPV) is a deadly virus that causes feline infectious peritonitis (FIP) in cats. FIP is a biotype of feline coronavirus (FCoV). Currently, the prevention and treatment of FIPV is challenged by the absence of adequate clinical treatment drugs and vaccines that offer strong immune protection complicated. In this review, we analyse and explain how small-molecule inhibitors function to protect against viral infections. Additionally, we highlight the challenges and future possibilities in developing FIPV vaccines, which are crucial for enhancing FIPV treatment and creating viable vaccine solution strategies.

摘要

猫传染性腹膜炎病毒（FIPV）是一种致命病毒，可导致猫患上猫传染性腹膜炎（FIP）。FIP是猫冠状病毒（FCoV）的一种生物型。目前，FIPV的预防和治疗面临挑战，因为缺乏足够的临床治疗药物和能提供强大免疫保护的疫苗。在这篇综述中，我们分析并解释小分子抑制剂如何发挥作用来预防病毒感染。此外，我们强调了开发FIPV疫苗所面临的挑战和未来的可能性，这对于加强FIPV治疗和制定可行的疫苗解决方案策略至关重要。