Liu Teng, Wendel Benjamin J, Huey Jennifer, Pandiyan Vimal Prabhu, Mustafi Debarshi, Chao Jennifer R, Sabesan Ramkumar
Department of Ophthalmology (T.L., B.W., J.H., V.P.P., D.M., J.R.C., R.S.), University of Washington, Seattle, Washington, USA; Department of Bioengineering (T.L., R.S.), University of Washington, Seattle, Washington, USA.
Department of Ophthalmology (T.L., B.W., J.H., V.P.P., D.M., J.R.C., R.S.), University of Washington, Seattle, Washington, USA.
Am J Ophthalmol. 2025 May 28;277:375-386. doi: 10.1016/j.ajo.2025.05.032.
To examine whether optoretinography (ORG) can provide greater sensitivity for assessing the time-course of disease progression in Retinitis Pigmentosa (RP) compared to standard clinical imaging in a longitudinal study.
Cohort study.
Five non-syndromic RP patients and 8 control subjects participated in the study.
Clinical examination, imaging sessions and data analysis were all conducted at the University of Washington. Five eyes of 5 patients diagnosed with RP, comparing standard clinical imaging to ORG, were collected over a 21-month span between August 2022 and May 2024.
ORG response to visual stimuli, ellipsoid zone (EZ) width and outer segment length (OS length) were evaluated for longitudinal changes as markers of disease progression.
The reduction in cone function with ORG over time exceeds that observed in standard clinical markers of photoreceptor structure - EZ width and OS length. EZ width and OSL decreased by 4.5% ± 5.9% and 6.5% ± 1.4%, respectively, approximately 9.9 and 6.9 times less than the reduction noted in ORG, respectively. The most notable degradation was noted at the borders of the transition zone, where ORG showed progressive and sub-clinical losses in photoreceptor function whereas standard OCT showed currently intact outer retinal structure.
Optoretinography detects sub-clinical disease and reliably identifies longitudinal markers of progression with greater sensitivity compared to standard clinical imaging. The ability to detect functional changes in the outer retina prior to standard clinical measures underscores its potential as a sensitive, accelerated and clinically-relevant outcome measure to guide patient selection and their therapeutic response in future clinical trials.
在一项纵向研究中，检验与标准临床成像相比，视网膜电图（ORG）在评估视网膜色素变性（RP）疾病进展的时间进程方面是否能提供更高的敏感性。
队列研究。
5名非综合征性RP患者和8名对照受试者参与了该研究。
临床检查、成像检查和数据分析均在华盛顿大学进行。在2022年8月至2024年5月的21个月期间，收集了5名被诊断为RP患者的5只眼睛，将标准临床成像与ORG进行比较。
评估ORG对视觉刺激的反应、椭圆体带（EZ）宽度和外段长度（OS长度）的纵向变化，作为疾病进展的标志物。
随着时间的推移，ORG检测到的视锥细胞功能下降超过了光感受器结构的标准临床标志物——EZ宽度和OS长度所观察到的下降。EZ宽度和OSL分别下降了4.5%±5.9%和6.5%±1.4%，分别比ORG中观察到的下降少约9.9倍和6.9倍。在过渡区边界观察到最显著的退化，ORG显示光感受器功能逐渐出现亚临床损失，而标准光学相干断层扫描（OCT）显示目前外层视网膜结构完整。
与标准临床成像相比，视网膜电图能检测亚临床疾病，并以更高的敏感性可靠地识别疾病进展的纵向标志物。在标准临床测量之前检测外层视网膜功能变化的能力突出了其作为一种敏感、快速且与临床相关的结局指标的潜力，可用于指导未来临床试验中的患者选择及其治疗反应。
