Štrublová Lucie, Zlámal Filip, Pískovský Tomáš, Kučera Jan, Kučerová Jana Fialová, Kepák Tomáš, Štěrba Jaroslav, Bienertová-Vašků Julie
Department of Pathological Physiology, Faculty of Medicine, Masaryk University, Brno, Czech Republic.
St. Anne's University Hospital (Brno) & International Clinical Research Centre (FNUSA- ICRC), Brno, Czech Republic.
Sci Rep. 2025 May 30;15(1):19005. doi: 10.1038/s41598-025-03013-8.
This retrospective, cross-sectional study investigated the relationship between body composition and circulating plasma levels of follistatin-like proteins (FSTLs; FSTL1, FSTL4, and FSTL5) in adult survivors of childhood cancer. This is the first study to investigate the association between plasma levels of FSTL4, FSTL5 and skeletal muscle mass. The cohort consisted of 61 CCS (26 females and 35 males) aged 18-36 years (mean age 24.6 ± 4.4 years) who were followed up at the Long-Term Follow-Up Clinic of St. Anne's Hospital in Brno, Czech Republic. The mean age at diagnosis was 10.9 ± 4.9 years, and the mean time after treatment was 12.0 ± 5.1 years. Body composition was assessed using anthropometric indicators and bioelectrical impedance analysis (BIA; InBody 370). Plasma FSTL levels were quantified using commercially available ELISA kits. Correlations were examined by linear regression analysis. A significant negative correlation was found between the FSTL1 plasma level and body fat mass index (BFMI), and a significant positive correlation was observed between FSTL1 and skeletal muscle mass index (SMI). Our results suggest that FSTL1 may be a potential indicator of adiposity and skeletal muscle loss in CCS.
这项回顾性横断面研究调查了儿童癌症成年幸存者的身体成分与循环血浆中卵泡抑素样蛋白（FSTLs；FSTL1、FSTL4和FSTL5）水平之间的关系。这是第一项研究FSTL4、FSTL5血浆水平与骨骼肌质量之间关联的研究。该队列由61名儿童癌症幸存者（26名女性和35名男性）组成，年龄在18 - 36岁之间（平均年龄24.6±4.4岁），他们在捷克共和国布尔诺圣安妮医院的长期随访诊所接受随访。诊断时的平均年龄为10.9±4.9岁，治疗后的平均时间为12.0±5.1年。使用人体测量指标和生物电阻抗分析（BIA；InBody 370）评估身体成分。使用市售ELISA试剂盒对血浆FSTL水平进行定量。通过线性回归分析检查相关性。发现FSTL1血浆水平与体脂质量指数（BFMI）之间存在显著负相关，FSTL1与骨骼肌质量指数（SMI）之间存在显著正相关。我们的结果表明，FSTL1可能是儿童癌症幸存者肥胖和骨骼肌丢失的潜在指标。
