Department of Radiology, Jen-Ai Hospital, Taichung, Taiwan.
Department of Physical Medicine and Rehabilitation, Puzi Hospital, Ministry of Health and Welfare, Chiayi, Taiwan.
Sci Rep. 2024 Nov 25;14(1):29127. doi: 10.1038/s41598-024-80721-7.
Bone mineral density (BMD) is a crucial indicator of osteoporosis. Bioelectrical impedance analysis (BIA) introduces a new method for assessing body composition, specifically BMD measurement. Compared with existing ultrasound and dual-energy X-ray absorptiometry for BMD screening and diagnosis, BIA has the advantages of safety, convenience and speed. However, the accuracy of BIA for BMD measurement needs to be explored. This study aimed to evaluate the accuracy of the novel BIA technique in conducting whole-body BMD assessments in the general population of Taiwan. Overall, 318 healthy adults in Taiwan (37.67 ± 19.44 years of age; 145 male and 173 female patients) were included. Whole-body BMD was measured via foot-to-foot BIA-StarBIA-201 (StarBIA Meditek Co. LTD, Taichung, Taiwan) and the dual-energy X-ray absorptiometry (DXA) Lunar Prodigy technology (GE Medical Systems, Madison, WI, USA). Linear regression analysis, Pearson's correlation coefficient, the Bland-Altman plot, and paired t tests were used. The whole-body BMDs measured by BIA and DXA were 1.139 ± 0.124 g/cm and 1.202 ± 0.168 g/cm, respectively. The regression equation was y = 1.057x + 0.063. The Pearson correlation coefficient, mean difference, and limits of agreement were r = 0.737, - 0.053 g/cm, and - 0.290-0.165 g/cm, respectively. The regression equation was y = 1.057x + 0.063. The Pearson correlation coefficient, mean difference, and limits of agreement were r = 0.737 (p < 0.001), - 0.053 g/cm, and - 0.290-0.165 g/cm, respectively. Standing BIA was correlated with the DXA gold standard for estimating whole-body BMD in adults; however, its interchangeability remains limited. The potential bias in the measurement results of this study represents a current challenge with BIA compared with that of DXA, and there is still room for improvement. The convenient BIA method for measuring whole-body BMD may be useful in the application of primary screening and future development of BMD assessment methods. BIA is widely used to measure body composition, but its application to the measurement of BMD represents a novel technological breakthrough.
骨密度（BMD）是骨质疏松症的一个关键指标。生物电阻抗分析（BIA）为评估身体成分，特别是 BMD 测量，引入了一种新方法。与现有的用于 BMD 筛查和诊断的超声和双能 X 射线吸收法相比，BIA 具有安全、方便和快速的优点。然而，BIA 测量 BMD 的准确性需要进一步研究。本研究旨在评估新型 BIA 技术在评估台湾一般人群全身 BMD 中的准确性。
总体而言，研究纳入了 318 名台湾健康成年人（37.67±19.44 岁；145 名男性和 173 名女性）。全身 BMD 通过足底-足底 BIA-StarBIA-201（StarBIA Meditek Co. LTD，台中，台湾）和双能 X 射线吸收法（DXA）Lunar Prodigy 技术（GE Medical Systems，麦迪逊，WI，美国）进行测量。使用线性回归分析、皮尔逊相关系数、Bland-Altman 图和配对 t 检验。BIA 和 DXA 测量的全身 BMD 分别为 1.139±0.124 g/cm 和 1.202±0.168 g/cm。回归方程为 y=1.057x+0.063。皮尔逊相关系数、平均差值和一致性界限分别为 r=0.737、-0.053 g/cm 和-0.290-0.165 g/cm。回归方程为 y=1.057x+0.063。皮尔逊相关系数、平均差值和一致性界限分别为 r=0.737（p<0.001）、-0.053 g/cm 和-0.290-0.165 g/cm。站立 BIA 与 DXA 金标准评估成人全身 BMD 相关；然而，其可互换性仍然有限。与 DXA 相比，本研究测量结果的潜在偏差代表了 BIA 的当前挑战，仍有改进的空间。BIA 测量全身 BMD 的便捷方法可能在初级筛查的应用和未来 BMD 评估方法的发展中有用。BIA 广泛用于测量身体成分，但它在 BMD 测量中的应用代表了一种新的技术突破。
